Historique
Article de Périodique
Detection and quantification of synthetic cannabinoids in seven illicitly sourced disposable vapes submitted by an individual presenting to a UK drug and alcohol service (2025)
Auteur(s) :
CRAFT, S. ;
SUNDERLAND, P. ;
MILLEA, M. F. ;
PUDNEY, C. R. ;
SUTCLIFFE, O. B. ;
FREEMAN, T. P.
Année :
2025
Page(s) :
549-554
Langue(s) :
Anglais
Refs biblio. :
20
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus géographique
ROYAUME-UNI
Thésaurus mots-clés
CANNABINOIDES
;
E-CIGARETTE
;
MESURES QUANTITATIVES
;
CANNABIS
;
PRODUIT ILLICITE
;
ETUDE TRANSVERSALE
;
MESURES QUALITATIVES
;
ANALYSE CHIMIQUE
;
EFFET SECONDAIRE
;
PHENOMENE EMERGENT
;
TOXICITE
;
TOXICOLOGIE
Note générale :
Commentary: Copeland C.S. Commentary on Craft et al.: Drug contaminants and substitutions in illicit vapes represent a major health risk. Addiction, 2025, Vol. 120, n° 3, p. 555-556. https://doi.org/10.1111/add.16777
Résumé :
BACKGROUND AND AIMS: In the United Kingdom and internationally, synthetic cannabinoids (SCs) are a common adulterant in illicitly sourced vaping products. Recently, their use is increasingly being linked to severe health effects, particularly among children. Here, we aimed to conduct the first detection and quantification of SCs in illicit disposable vaping products.
METHODS: A cross-section of seven illicitly sourced disposable vape samples that were initially sold as cannabis products was submitted for analysis by a single individual presenting to a drug and alcohol service in the United Kingdom. Qualitative and quantitative analyses of these samples were conducted using nuclear magnetic resonance and gas chromatography/electron ionization-mass spectrometry.
RESULTS: Qualitative analysis identified the SC 5F-MDMB-PICA in all seven samples, in the absence of any other pharmacologically active compounds. Quantitative analysis revealed that the median concentration of 5F-MDMB-PICA was 0.85 mg/ml (range = 0.59-1.63). The external appearance of these vape samples closely resembled regulated vaping products, and the presence of SCs was not identifiable by any labelling or packaging.
CONCLUSIONS: The SC 5F-MDMB-PICA was detected at a median concentration of 0.85 mg/ml in seven disposable vapes which were illegally sourced in the United Kingdom, were mis-sold as cannabis products and closely resembled legal, regulated products. [Author's abstract]
METHODS: A cross-section of seven illicitly sourced disposable vape samples that were initially sold as cannabis products was submitted for analysis by a single individual presenting to a drug and alcohol service in the United Kingdom. Qualitative and quantitative analyses of these samples were conducted using nuclear magnetic resonance and gas chromatography/electron ionization-mass spectrometry.
RESULTS: Qualitative analysis identified the SC 5F-MDMB-PICA in all seven samples, in the absence of any other pharmacologically active compounds. Quantitative analysis revealed that the median concentration of 5F-MDMB-PICA was 0.85 mg/ml (range = 0.59-1.63). The external appearance of these vape samples closely resembled regulated vaping products, and the presence of SCs was not identifiable by any labelling or packaging.
CONCLUSIONS: The SC 5F-MDMB-PICA was detected at a median concentration of 0.85 mg/ml in seven disposable vapes which were illegally sourced in the United Kingdom, were mis-sold as cannabis products and closely resembled legal, regulated products. [Author's abstract]
Affiliation :
Addiction and Mental Health Group, Department of Psychology, University of Bath, Bath, UK.
Department of Life Sciences, University of Bath, Bath, UK.
MANchester DRug Analysis and Knowledge Exchange (MANDRAKE), Manchester Metropolitan University, Manchester, UK.
Department of Life Sciences, University of Bath, Bath, UK.
MANchester DRug Analysis and Knowledge Exchange (MANDRAKE), Manchester Metropolitan University, Manchester, UK.
Cote :
Abonnement électronique