|Titre :||The frequency of severe Fetal Alcohol Spectrum Disorders in the neonatal period using data from the French hospital discharge database between 2006 and 2013 (2021)|
|Auteurs :||V. DEMIGUEL ; S. LAPORAL ; G. QUATREMÈRE ; Y. BARRY ; I. GUSEVA CANU ; V. GOULET ; D. GERMANAUD ; N. REGNAULT|
|Type de document :||Article : Périodique|
|Dans :||Drug and Alcohol Dependence (Vol.225, August 2021)|
|Article en page(s) :||art. 108748|
|Discipline :||EPI (Epidémiologie / Epidemiology)|
Thésaurus TOXIBASEALCOOL ; SYNDROME D'ALCOOLISATION FOETALE ; HOPITAL ; EVOLUTION ; CLASSIFICATION INTERNATIONALE DES MALADIES ; NOUVEAU-NE ; BASE DE DONNEES ; REGION
Backgrounds: At birth, only complete Fetal Alcohol Syndrome (FAS) can be properly diagnosed. However, other Consequences of prenatal Alcohol Exposure (CAE) can also be recorded. Our objective was to describe the frequency of diagnoses highly suggestive of "potential Fetal Alcohol Syndrome Disorder" (pFASD, i.e., FAS and CAE) among hospitalized neonates, during the neonatal period, in France, between 2006 and 2013.
Methods: We used the French national hospital discharge database to identify the Q86.0 (FAS) and P04.3 (CAE) ICD-10 codes in hospital stays occurring in the first 28 days of life. FAS, CAE and pFASD rates were estimated per 1000 live births at the national level for the 2009-2013 period. We compared the 2006-2009 and 2010-2013 rates. The pFASD rates were also estimated at the regional level.
Results: Overall, 3,207 cases of pFASD were diagnosed during the neonatal period (i.e., 0.48 cases per 1000 live births, including 0.07 cases of FAS per 1000). Between 2006-2009 and 2010-2013, pFASD remained stable, despite a moderate decrease in reported FAS (0.08 vs 0.06 cases per 1000, p < 0.001). At the regional level, pFASD rates varied between 0.13 and 1.22 cases per 1000.
Conclusions: This study provides the first national estimate of neonatal diagnosis of FAS, and more broadly pFASD, in France. Although our data certainly underestimate the real prevalence of FASD, they provide a minimal estimate of the burden of alcohol use during pregnancy. Observed variations deserve to be analyzed in the light of concomitant prevention and public information campaigns.
• First French national estimate of potential FASD using medico administrative data.
• Stable rate of potential FASD and increased frequency of FAS between 2006 and 2013.
• Regional variability may be explained by local mobilization around pFASD diagnosis.
• A low range for estimating the burden of prenatal alcohol exposure at birth.
• Active surveillance could be initiated considering the public health burden.
|Domaine :||Alcool / Alcohol|
|Affiliation :||Santé publique France, French National Public Health Agency, Saint-Maurice, France|