|Titre :||Implementation and evaluation of an educational intervention for safer injection in people who inject drugs in Europe: a multi-country mixed-methods study (2021)|
|Auteurs :||P. ROUX ; C. DONADILLE ; C. MAGEN ; E. SCHATZ ; R. STRANZ ; A. CURADO ; T. TSIAKOU ; L. VERDES ; A. ALEKSOVA ; P. CARRIERI ; S. MEZAACHE ; A. BEN CHARIF|
|Type de document :||Article : Périodique|
|Dans :||International Journal of Drug Policy (Vol.87, January 2021)|
|Article en page(s) :||art. 102992|
|Discipline :||PRE (Prévention - RdRD / Prevention - Harm reduction)|
Thésaurus GéographiqueEUROPE ; BULGARIE ; GRECE ; PORTUGAL ; ROUMANIE
Thésaurus TOXIBASEINJECTION ; INTERVENTION ; REDUCTION DES RISQUES ET DES DOMMAGES ; EDUCATION POUR LA SANTE ; PARTAGE DE SERINGUE ; USAGER ; EVALUATION ; EFFICACITE ; PRODUIT ILLICITE
Background: Harm reduction (HR) interventions are essential to reduce human immunodeficiency virus (HIV) and hepatitis C virus (HCV) transmission in people who inject drugs (PWID). Preliminary testing of the Individually Tailored Support and Education for Safer Injection (ITSESI) evidence-based educational intervention for PWID was performed in France in 2011. We created the Eurosider project to implement and evaluate ITSESI at a wider European level, with a view to its future pan-European diffusion.
Methods: We performed a mixed-methods study involving quantitative (a 6-month before-after study with PWID) and qualitative (focus groups with field workers) components. The study was conducted in 2018-2019 with 307 eligible PWID participating in four existing HR programmes in Bulgaria, Greece, Portugal, and Romania. ITSESI consists in trained field workers observing PWID injection practices and providing an educational exchange. For the present study, PWID participants were allocated to either the control group (i.e., they continued receiving only the current HR services) or the intervention group (i.e., current HR services plus ITSESI). We used the RE-AIM QuEST framework to assess the effectiveness of ITSESI and its acceptability by field workers. Effectiveness was defined as a reduction in both syringe sharing - the highest HIV/HCV transmission risk practice - and in cutaneous abscesses. We used a multivariable mixed logit model to analyse both effectiveness outcomes and to provide adjusted odds ratios (aOR) and 95% confidence intervals (CI). Field workers' acceptability of the intervention was described using a thematic analysis of the qualitative data.
Results: Of the 307 PWID, 55% received ITSESI. Syringe sharing and cutaneous abscesses decreased during follow-up in the intervention group (from 25 to 16% and from 27 to 14%, respectively). Reductions were smaller in the control group (from 29 to 24% and from 23 to 18%, respectively). The multivariable analyses confirmed the effect of the intervention on both of these outcomes (aOR [95% CI]: 0.38 [0.17, 0.85]) and (aOR [95% CI]: 0.38 [0.16, 0.90], respectively). Our qualitative data on acceptability showed the feasibility of involving field workers as proactive research partners in making ITSESI more accessible and acceptable across Europe.
Conclusions: We demonstrated both the effectiveness of ITSESI in reducing syringe sharing and cutaneous abscesses in four European countries, and a high level of intervention acceptability by field workers. Our findings provide important insights into how ITSESI can be adapted for pan-European implementation.
• The Individually Tailored Support and Education for Safer Injection (ITSESI) intervention helps reduce both the HIV/HCV transmission risk practice of syringe sharing and cutaneous abscesses in PWID.
• The implementation of an educational intervention for people who inject drugs (PWID) is feasible in the European context, provided that access to needle and syringe programmes and financial means for human resources are guaranteed.
• Harm reduction interventions must be adapted to local drug policy contexts in order to avoid harms related to repression.
• The use of mixed-methods and community-based participatory approaches ensures more efficient implementation and evaluation of the ITSESI.
|Domaine :||Drogues illicites / Illicit drugs|
|Affiliation :||Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques and Sociales de la Santé and Traitement de l'Information Médicale, Marseille, France|