Historique
Article de Périodique
HCV-related mortality among HIV/HCV co-infected patients: The importance of behaviors in the HCV cure era (ANRS CO13 HEPAVIH Cohort) (2020)
Auteur(s) :
M. E. SANTOS ;
C. PROTOPOPESCU ;
P. SOGNI ;
I. YAYA ;
L. PIROTH ;
F. BAILLY ;
F. MARCELLIN ;
L. ESTERLE ;
L. WITTKOP ;
E. ROSENTHAL ;
P. MORLAT ;
P. ROUX ;
W. N. DE ARAUJO ;
D. SALMON-CERON ;
M. P. CARRIERI ;
ANRS CO13-HEPAVIH Study Group
Article en page(s) :
1069-1084
Refs biblio. :
52
Domaine :
Alcool / Alcohol ; Drogues illicites / Illicit drugs ; Tabac / Tobacco / e-cigarette
Langue(s) :
Anglais
Discipline :
MAL (Maladies infectieuses / Infectious diseases)
Résumé :
Mortality among individuals co-infected with HIV and hepatitis C virus (HCV) is relatively high. We evaluated the association between psychoactive substance use and both HCV and non-HCV mortality in HIV/HCV co-infected patients in France, using Fine and Gray's competing-risk model adjusted for socio-demographic, clinical predictors and confounding factors, while accounting for competing causes of death. Over a 5-year median follow-up period, 77 deaths occurred among 1028 patients. Regular/daily cannabis use, elevated coffee intake, and not currently smoking were independently associated with reduced HCV-mortality (adjusted sub-hazard ratio [95% CI] 0.28 [0.10-0.83], 0.38 [0.15-0.95], and 0.28 [0.10-0.79], respectively). Obesity and severe thinness were associated with increased HCV-mortality (2.44 [1.00-5.93] and 7.25 [2.22-23.6] versus normal weight, respectively). Regular binge drinking was associated with increased non-HCV-mortality (2.19 [1.10-4.37]). Further research is needed to understand the causal mechanisms involved. People living with HIV/HCV co-infection should be referred for tobacco, alcohol and weight control interventions and potential benefits of cannabis-based therapies investigated.
Affiliation :
INSERM, IRD, SESSTIM, Sciences Economiques, & Sociales de la Santé & Traitement de l'Information Médicale, Aix Marseille Université, Marseille, France