| Titre : | HCV-related mortality among HIV/HCV co-infected patients: The importance of behaviors in the HCV cure era (ANRS CO13 HEPAVIH Cohort) (2020) |
| Auteurs : | M. E. SANTOS ; C. PROTOPOPESCU ; P. SOGNI ; I. YAYA ; L. PIROTH ; F. BAILLY ; F. MARCELLIN ; L. ESTERLE ; L. WITTKOP ; E. ROSENTHAL ; P. MORLAT ; P. ROUX ; W. N. DE ARAUJO ; D. SALMON-CERON ; M. P. CARRIERI ; ANRS CO13-HEPAVIH Study Group |
| Type de document : | Article : Périodique |
| Dans : | AIDS and Behavior (Vol.24, n°4, April 2020) |
| Article en page(s) : | 1069-1084 |
| Langues: | Anglais |
| Discipline : | MAL (Maladies infectieuses / Infectious diseases) |
| Mots-clés : |
Thésaurus géographique FRANCEThésaurus mots-clés VIH ; HEPATITE ; MORTALITE ; COHORTE ; COINFECTION ; ALCOOL ; TABAC ; FACTEUR DE RISQUE ; CANNABIS ; CAFE |
| Résumé : | Mortality among individuals co-infected with HIV and hepatitis C virus (HCV) is relatively high. We evaluated the association between psychoactive substance use and both HCV and non-HCV mortality in HIV/HCV co-infected patients in France, using Fine and Gray's competing-risk model adjusted for socio-demographic, clinical predictors and confounding factors, while accounting for competing causes of death. Over a 5-year median follow-up period, 77 deaths occurred among 1028 patients. Regular/daily cannabis use, elevated coffee intake, and not currently smoking were independently associated with reduced HCV-mortality (adjusted sub-hazard ratio [95% CI] 0.28 [0.10-0.83], 0.38 [0.15-0.95], and 0.28 [0.10-0.79], respectively). Obesity and severe thinness were associated with increased HCV-mortality (2.44 [1.00-5.93] and 7.25 [2.22-23.6] versus normal weight, respectively). Regular binge drinking was associated with increased non-HCV-mortality (2.19 [1.10-4.37]). Further research is needed to understand the causal mechanisms involved. People living with HIV/HCV co-infection should be referred for tobacco, alcohol and weight control interventions and potential benefits of cannabis-based therapies investigated. |
| Domaine : | Alcool / Alcohol ; Drogues illicites / Illicit drugs ; Tabac / Tobacco |
| Refs biblio. : | 52 |
| Affiliation : | INSERM, IRD, SESSTIM, Sciences Economiques, & Sociales de la Santé & Traitement de l'Information Médicale, Aix Marseille Université, Marseille, France |
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