Titre : | A case report of carfentanil-related fatality in France (2019) |
Auteurs : | J. M. GAULIER ; C. RICHEVAL ; M. PHANITHAVONG ; S. BRAULT ; D. ALLORGE ; V. DUMESTRE-TOULET |
Type de document : | Article : Périodique |
Dans : | Toxicologie Analytique et Clinique (Vol.31, n°4, Décembre 2019) |
Article en page(s) : | 323-331 |
Langues: | Anglais |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus géographique FRANCEThésaurus mots-clés ETUDE DE CAS ; FENTANYL ; MORTALITE ; ANALYSE CHIMIQUE ; MEDECINE LEGALE ; TOXICOLOGIE ; METABOLITE |
Résumé : | Today, NPS are increasingly being related to post-mortem cases, and this problem drastically intensifies as a result of the New Synthetic Opioids (NSOs) surge. Among NSOs, carfentanil (CaF) is the most potent fentanyl analogue and was central to a large number of NSOs-related fatalities in North America, as well as in UE, since 2016. In this worrisome context, this manuscript reports the first CaF-related fatality occurred in France. A 41-years-old man was found dead with a syringe planted under his tongue. This man has a psychiatric follow-up for opiate addiction and his recent medical history included intoxication with fentanyl derivatives. Toxicological investigations of post-mortem samples (blood, urine and hair), and syringe were requested. CaF (with several other psychoactive drugs at non-toxic level) was detected in biological samples and in syringe residue using LC-HRMS, and quantified using LC-MS/MS in blood, urine and hair (from proximal to distal hair section - 3cm length each) at 4.20, 0.40 µg/L and 54/114/166 pg/mg, respectively. The relatively high post-mortem CaF blood concentration together with the absence of metabolite (especially NorCaF) suggests a sudden death of the victim immediately following a significant CaF dose intake (presumably injected) that can explain the decease. |
Domaine : | Autres substances / Other substances |
Sous-type de document : | Etude de cas / Case report |
Refs biblio. : | 58 |
Affiliation : | Unité fonctionnelle de toxicologie, CHU de Lille, Lille, France |
Cote : | Abonnement |
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