|Titre :||The prevalence of non-fatal overdose among people who inject drugs: A multi-stage systematic review and meta-analysis (2019)|
|Auteurs :||S. COLLEDGE ; A. PEACOCK ; J. LEUNG ; S. LARNEY ; J. GREBELY ; M. HICKMAN ; E. CUNNINGHAM ; A. TRICKEY ; J. STONE ; P. VICKERMAN ; L. DEGENHARDT|
|Type de document :||Article : Périodique|
|Dans :||International Journal of Drug Policy (Vol.73, November 2019)|
|Article en page(s) :||172-184|
|Discipline :||EPI (Epidémiologie / Epidemiology)|
Thésaurus TOXIBASEINJECTION ; SURDOSE ; PREVALENCE ; OPIOIDES ; MORTALITE ; USAGER
Background: People who inject drugs (PWID) are at an elevated risk of fatal overdose in the first year after experiencing a non-fatal event. Such non-fatal events may also result in overdose-related sequelae, ranging from physical injury to paralysis. Given variation in drug markets and treatment availability across countries and regions, we may see similar variations in non-fatal overdose prevalence. Monitoring non-fatal overdose prevalence among PWID is essential for informing treatment intervention efforts, and thus our review aims to estimate the global, regional, and national prevalence of non-fatal overdose, and determine characteristics associated with experiencing such an event.
Methods: We conducted a systematic review and meta-analyses to estimate country, regional, and global estimates of recent and lifetime non-fatal overdose prevalence among PWID. Using meta-regression analyses we also determined associations between sample characteristics and non-fatal overdose prevalence.
Results: An estimated 3.2 (1.8-5.2) million PWID have experienced at least one overdose in the previous year. Among PWID, 20.5% (15.0-26.1%) and 41.5% (34.6-48.4%) had experienced a non-fatal event in the previous 12 months and lifetime respectively. Frequent injecting was strongly associated with PWID reporting recent and lifetime non-fatal overdose. Estimates of recent non-fatal overdose were particularly high in Asia and North America.
Conclusion: Around one in five PWID are at an elevated risk of fatally overdosing every year, however there is substantial geographical variation. In countries with higher rates of non-fatal overdose there is need to introduce or mainstream overdose prevention strategies such as opioid agonist treatment and naloxone administration training programs.
|Domaine :||Drogues illicites / Illicit drugs|
|Sous-type de document :||Méta-analyse / Meta-analysis ; Revue de la littérature / Literature review|
|Affiliation :||National Drug and Alcohol Research Centre, UNSW Sydney, Sydney, Australia|