Historique
Article de Périodique
A capture-recapture method for estimating the incidence of off-label prescriptions: the example of baclofen for alcohol use disorder in France (2019)
Auteur(s) :
AUFFRET, M. ;
ROLLAND, B. ;
BEHAL, H. ;
LABREUCHE, J. ;
JOUANJUS, E. ;
BORDET, R. ;
GAUTIER, S.
Année :
2019
Page(s) :
645-650
Langue(s) :
Anglais
Refs biblio. :
26
Domaine :
Alcool / Alcohol ; Autres substances / Other substances
Discipline :
EPI (Epidémiologie / Epidemiology)
Thésaurus géographique
FRANCE
;
NORD-PAS DE CALAIS
Thésaurus mots-clés
ETUDE CLINIQUE
;
BACLOFENE
;
CAPTURE-RECAPTURE
;
PRESCRIPTION MEDICALE
;
INCIDENCE
;
MODELE
Résumé :
The local/regional incidence of off-label prescriptions can be difficult to estimate. Capture-recapture models can be used to indirectly estimate population sizes. Here, we used a capture-recapture model to estimate the number of patients treated off-label with baclofen for alcohol use disorder in northern France in 2013. Three capture sources were used: (i) the active case file at the region's largest Addiction Unit, (ii) the regional pharmacovigilance centre, and (iii) a sample of community pharmacies. After between-source overlaps had been identified, we used a log-linear model to produced eight estimates. Two models displayed the best goodness-of-fit, with estimates [95% confidence interval] of 1123 [714-2162] and 2180 [1598-2870] subjects, respectively. These two values are in line with a previous estimate of 1624 patients, based on an analysis of the French national health insurance database in 2013. Capture-recapture methods can be usefully applied to estimate the prevalence of OLPs in a specific geographical area, when direct counting is not feasible or the estimate through claim database is not possible.
Affiliation :
Centre régional de pharmacovigilance, hospices civils de Lyon, CHU de Lyon, Lyon, France