| Titre : | A capture-recapture method for estimating the incidence of off-label prescriptions: the example of baclofen for alcohol use disorder in France (2019) |
| Auteurs : | M. AUFFRET ; B. ROLLAND ; H. BEHAL ; J. LABREUCHE ; E. JOUANJUS ; R. BORDET ; S. GAUTIER |
| Type de document : | Article : Périodique |
| Dans : | Thérapie (Online first 20/06/2019) |
| Article en page(s) : | doi: 10.1016/j.therap.2019.06.002 |
| Langues: | Anglais |
| Discipline : | EPI (Epidémiologie / Epidemiology) |
| Mots-clés : |
Thésaurus TOXIBASE ETUDE CLINIQUE ; BACLOFENE ; CAPTURE-RECAPTURE ; PRESCRIPTION MEDICALE ; INCIDENCE ; MODELEThésaurus Géographique FRANCE ; NORD-PAS DE CALAIS |
| Résumé : | The local/regional incidence of off-label prescriptions can be difficult to estimate. Capture-recapture models can be used to indirectly estimate population sizes. Here, we used a capture-recapture model to estimate the number of patients treated off-label with baclofen for alcohol use disorder in northern France in 2013. Three capture sources were used: (i) the active case file at the region's largest Addiction Unit, (ii) the regional pharmacovigilance centre, and (iii) a sample of community pharmacies. After between-source overlaps had been identified, we used a log-linear model to produced eight estimates. Two models displayed the best goodness-of-fit, with estimates [95% confidence interval] of 1123 [714-2162] and 2180 [1598-2870] subjects, respectively. These two values are in line with a previous estimate of 1624 patients, based on an analysis of the French national health insurance database in 2013. Capture-recapture methods can be usefully applied to estimate the prevalence of OLPs in a specific geographical area, when direct counting is not feasible or the estimate through claim database is not possible. |
| Domaine : | Alcool / Alcohol ; Autres substances / Other substances |
| Refs biblio. : | 26 |
| Affiliation : | Centre régional de pharmacovigilance, hospices civils de Lyon, CHU de Lyon, Lyon, France |
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