Article de Périodique
Concomitant heroin and cocaine use among opioid-dependent patients during methadone, buprenorphine or morphine opioid agonist therapy (2019)
Auteur(s) :
GASTBERGER, S. ;
BAUMGARTNER, M. R. ;
SOYKA, M. ;
QUEDNOW, B. B. ;
HULKA, L. M. ;
HERDENER, M. ;
SEIFRITZ, E. ;
MUTSCHLER, J.
Année :
2019
Page(s) :
207-212
Langue(s) :
Anglais
Refs biblio. :
32
Domaine :
Autres substances / Other substances ; Drogues illicites / Illicit drugs
Thésaurus géographique
SUISSE
Thésaurus mots-clés
POLYCONSOMMATION
;
METHADONE
;
BUPRENORPHINE
;
MORPHINE
;
HEROINE
;
COCAINE
;
TRAITEMENT DE MAINTENANCE
;
ETUDE TRANSVERSALE
;
OPIACES
;
DEPISTAGE
;
COMPARAISON
;
SUBSTITUTION
Résumé :
BACKGROUND: Among all the treatment methods developed so far, opioid agonist treatment (OAT) is the most effective therapy for opioid dependence. While methadone (MTD) is the most commonly used, fewer data are available on alternative opioid agonist. The aim of this study was to assess the efficacy of buprenorphine (BUP) and slow-released morphine compared to MTD with regard to the reduction of concomitant heroin and cocaine use.
METHODS: This cross-sectional study included 105 patients receiving MTD, BUP, or slow-release morphine as opioid agonist therapy at the Psychiatric Hospital of Zurich. Illicit drug use was assessed using a retrospective 3-month hair toxicology analysis to quantify concentrations of heroin degradation products and metabolites, as well as cocaine and cocaine metabolites. We have also collected self-reports, but in the data of the study, only the results of the hair analysis were considered.
RESULTS: BUP-treated patients showed lower rates of illicit opiate consumption in comparison to the group treated with MTD or slow-released morphine (p CONCLUSION: This study suggests that BUP OAT is associated with reduced additional opiate co-use.
METHODS: This cross-sectional study included 105 patients receiving MTD, BUP, or slow-release morphine as opioid agonist therapy at the Psychiatric Hospital of Zurich. Illicit drug use was assessed using a retrospective 3-month hair toxicology analysis to quantify concentrations of heroin degradation products and metabolites, as well as cocaine and cocaine metabolites. We have also collected self-reports, but in the data of the study, only the results of the hair analysis were considered.
RESULTS: BUP-treated patients showed lower rates of illicit opiate consumption in comparison to the group treated with MTD or slow-released morphine (p CONCLUSION: This study suggests that BUP OAT is associated with reduced additional opiate co-use.
Affiliation :
Department of Psychiatry, Center for Addictive Disorders, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland
Cote :
Abonnement