|Titre :||The evolving drug epidemic of prescription opioid injection and its association with HCV transmission among people who inject drugs in Montreal, Canada (2019)|
|Auteurs :||J. BRUNEAU ; N. ARRUDA ; G. ZANG ; D. JUTRAS-ASWAD ; E. ROY|
|Type de document :||Article : Périodique|
|Dans :||Addiction (Vol.114, n°2, February 2019)|
|Article en page(s) :||366-373|
|Discipline :||MAL (Maladies infectieuses / Infectious diseases)|
Thésaurus TOXIBASEOPIOIDES ; INJECTION ; HEPATITE ; INCIDENCE ; EVOLUTION ; USAGER ; ETUDE PROSPECTIVE ; SEROPOSITIVITE ; INFECTION
AIMS: To examine temporal trends in prescription opioid (PO) injection and to assess its association with hepatitis C virus (HCV) seroconversion among people who inject drugs (PWID).
DESIGN: Prospective cohort study spanning 2004 to 2016.
SETTING: Montreal, Canada.
PARTICIPANTS: PWID reporting injection during the past 6 months.
MEASUREMENTS: PWID were recruited between 2004 and 2016. At each 3-6-month follow-up visit, participants completed interview-administered questionnaires and were tested for HCV-antibody.
FINDINGS: Among 1524 PWID [83% males, mean age 38 years, standard deviation (SD) = 10, 34% (31-36) prescription opioid (PO) injection past month] included in trends analyses, PO injection use expanded between 2004 and 2009, and plateaued between 2010 and 2016 (trend tests CONCLUSION: Prescription opioid injection increased among people who inject drugs in Montreal, Canada from 2004 to 2009, to reach a plateau between 2010 and 2016. The association between prescription opioid injection and HCV seroconversion was stronger during the second period than the first according to the epidemic phase.
|Domaine :||Autres substances / Other substances ; Drogues illicites / Illicit drugs|
|Refs biblio. :||33|
|Affiliation :||Research Center, Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada|