|Titre :||Age-varying effects of cannabis use frequency and disorder on symptoms of psychosis, depression and anxiety in adolescents and adults (2019)|
|Auteurs :||B. J. LEADBEATER ; M. E. AMES ; A. N. LINDEN-CARMICHAEL|
|Type de document :||Article : Périodique|
|Dans :||Addiction (Vol.114, n°2, February 2019)|
|Article en page(s) :||278-293|
|Discipline :||PSY (Psychopathologie / Psychopathology)|
Thésaurus TOXIBASEADOLESCENT ; ADULTE ; CANNABIS ; PSYCHOPATHOLOGIE ; PSYCHOSE ; DEPRESSION ; ANXIETE ; SYMPTOME ; ETUDE TRANSVERSALE ; INITIATION ; AGE ; EPIDEMIOLOGIE
AIMS: We tested the age-varying associations of cannabis use (CU) frequency and disorder (CUD) with psychotic, depressive and anxiety symptoms in adolescent and adult samples. Moderating effects of early onset (
DESIGN: Time-varying effect models were used to assess the significance of concurrent associations between CU and CUD and symptoms of psychosis, depression and anxiety at each age.
SETTING AND PARTICIPANTS: Adolescent data (V-HYS; n = 662) were collected from a randomly recruited sample of adolescents in Victoria, British Columbia, Canada during a 10-year period (2003-13). Adult cross-sectional data (NESARC-III; n = 36 309) were collected from a representative sample from the United States (2012-13).
MEASUREMENTS: Mental health symptoms were assessed using self-report measures of diagnostic symptoms. CU was based on frequency of past-year use. Past-year CUD was based on DSM-5 criteria.
FINDINGS: For youth in the V-HYS, CU was associated with psychotic symptoms following age 22 [b = 0.13, 95% confidence interval (CI) = 0.002, 0.25], with depressive symptoms from ages 16-19 and following age 25 (b = 0.17, 95% CI = 0.003, 0.34), but not with anxiety symptoms. CUD was associated with psychotic symptoms following age 23 (b = 0.51, 95% CI = 0.01, 1.01), depressive symptoms at ages 19-20 and following age 25 (b = 0.71, 95% CI = 0.001, 1.42) and anxiety symptoms ages 26-27 only. For adults in the NESARC-III, CU was associated with mental health symptoms at most ages [e.g. psychotic symptoms; age 18 (b = 0.22, 95% CI = 0.10, 0.33) to age 65 (b = 0.36, 95% CI = 0.16, 0.56)]. CUD was associated with all mental health symptoms across most ages [e.g. depressive symptoms; age 18 (b = 0.96, 95% CI = 0.19, 1.73) to age 61 (b = 1.11, 95% CI = 0.01, 2.21)]. Interactions with sex show stronger associations for females than males in young adulthood [e.g. V-HYS: CUD x sex interaction on psychotic symptoms significant after age 26 (b = 1.12, 95% CI = 0.02, 2.21)]. Findings were not moderated by early-onset CU.
CONCLUSIONS: Significant associations between cannabis use (CU) frequency and disorder (CUD) and psychotic and depressive symptoms in late adolescence and young adulthood extend across adulthood, and include anxiety.
|Domaine :||Drogues illicites / Illicit drugs|
|Refs biblio. :||36|
|Affiliation :||Department of Psychology, University of Victoria, Victoria, BC, Canada|