|Titre :||Adolescent cannabis use, baseline prodromal symptoms and the risk of psychosis (2018)|
|Auteurs :||A. MUSTONEN ; S. NIEMELA ; T. NORDSTROM ; G. K. MURRAY ; P. MAKI ; E. JAASKELAINEN ; J. MIETTUNEN|
|Type de document :||Article : Périodique|
|Dans :||British Journal of Psychiatry (Vol.212, n°4, April 2018)|
|Article en page(s) :||227-233|
|Discipline :||PSY (Psychopathologie / Psychopathology)|
Thésaurus TOXIBASECOHORTE ; ADOLESCENT ; CANNABIS ; PSYCHOSE ; FACTEUR DE RISQUE ; SYMPTOME ; ETUDE PROSPECTIVE ; PSYCHOPATHOLOGIE
Background: The association between cannabis use and the risk of psychosis has been studied extensively but the temporal order still remains controversial.
Aims: To examine the association between cannabis use in adolescence and the risk of psychosis after adjustment for prodromal symptoms and other potential confounders.
Method: The sample (n = 6534) was composed of the prospective general population-based Northern Finland Birth Cohort of 1986. Information on prodromal symptoms of psychosis and cannabis use was collected using questionnaires at age 15-16 years. Participants were followed up for ICD-10 psychotic disorders until age 30 years using nationwide registers.
Results: The risk of psychosis was elevated in individuals who had tried cannabis five times or more (hazard ratio, (HR) = 6.5, 95% CI 3.0-13.9). The association remained statistically significant even when adjusted for prodromal symptoms, other substance use and parental psychosis (HR = 3.0, 95% CI 1.1-8.0).
Conclusions: Adolescent cannabis use is associated with increased risk of psychosis even after adjustment for baseline prodromal symptoms, parental psychosis and other substance use.
Declaration of interest: None.
|Domaine :||Drogues illicites / Illicit drugs|
|Refs biblio. :||28|
|Affiliation :||Center for Life Course Health Research, University of Oulu, Oulu, Finland|