Titre : | Adolescent cannabis use, baseline prodromal symptoms and the risk of psychosis (2018) |
Auteurs : | A. MUSTONEN ; S. NIEMELA ; T. NORDSTROM ; G. K. MURRAY ; P. MAKI ; E. JAASKELAINEN ; J. MIETTUNEN |
Type de document : | Article : Périodique |
Dans : | British Journal of Psychiatry (Vol.212, n°4, April 2018) |
Article en page(s) : | 227-233 |
Langues: | Anglais |
Discipline : | PSY (Psychopathologie / Psychopathology) |
Mots-clés : |
Thésaurus géographique FINLANDEThésaurus mots-clés COHORTE ; ADOLESCENT ; CANNABIS ; PSYCHOSE ; FACTEUR DE RISQUE ; SYMPTOME ; ETUDE PROSPECTIVE ; PSYCHOPATHOLOGIE |
Résumé : |
Background: The association between cannabis use and the risk of psychosis has been studied extensively but the temporal order still remains controversial.
Aims: To examine the association between cannabis use in adolescence and the risk of psychosis after adjustment for prodromal symptoms and other potential confounders. Method: The sample (n = 6534) was composed of the prospective general population-based Northern Finland Birth Cohort of 1986. Information on prodromal symptoms of psychosis and cannabis use was collected using questionnaires at age 15-16 years. Participants were followed up for ICD-10 psychotic disorders until age 30 years using nationwide registers. Results: The risk of psychosis was elevated in individuals who had tried cannabis five times or more (hazard ratio, (HR) = 6.5, 95% CI 3.0-13.9). The association remained statistically significant even when adjusted for prodromal symptoms, other substance use and parental psychosis (HR = 3.0, 95% CI 1.1-8.0). Conclusions: Adolescent cannabis use is associated with increased risk of psychosis even after adjustment for baseline prodromal symptoms, parental psychosis and other substance use. Declaration of interest: None. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 28 |
Affiliation : | Center for Life Course Health Research, University of Oulu, Oulu, Finland |
URL : | https://web.archive.org/web/20180530090915/https://theconversation.com/consommer-du-cannabis-a-ladolescence-augmente-le-risque-de-schizophrenie-15-ans[...] |
Lien : | https://doi.org/10.1192/bjp.2017.52 |
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