Titre : | Determination of cannabinoid and synthetic cannabinoid metabolites in wastewater by liquid-liquid extraction and ultra-high performance supercritical fluid chromatography-tandem mass spectrometry (2018) |
Auteurs : | I. GONZALEZ-MARINO ; K. V. THOMAS ; M. J. REID |
Type de document : | Article : Périodique |
Dans : | Drug Testing and Analysis (Vol.10, n°1, January 2018) |
Article en page(s) : | 222-228 |
Langues: | Anglais |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus mots-clés ANALYSE CHIMIQUE ; EAUX USEES ; METHODE ; CANNABINOIDES ; DROGUES DE SYNTHESE ; METABOLITE |
Résumé : | For the first time, ultra-high performance supercritical fluid chromatography (UHPSFC) coupled to tandem mass spectrometry has been used to determine cannabinoid and synthetic cannabinoid residues in wastewater. Combined with a downscaled version of the classic liquid-liquid extraction, the proposed method allows for the quantification of Delta9-tetrahydrocannabinol, three of its major metabolites (the monohydroxylated, the dehydroxylated, and the carboxylated species) and four synthetic cannabinoid metabolites (from the JWH-series) at low ng L-1 levels. Limits of quantification are in the 1-59 ng L-1 range, with recovery between 62 and 122% in ultrapure water and between 59 and 138% in wastewater. The applicability of the developed methodology was confirmed by the analysis of real wastewater, where cannabis metabolites could be positively quantified in all the samples analyzed. It is, therefore, a fast and simple alternative to common solid-phase extraction-liquid chromatography-mass spectrometry procedures for the determination of these low polar substances in water. Copyright © 2017 John Wiley & Sons, Ltd. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 15 |
Affiliation : | Institute for Food Analysis and Research (IIAA), University of Santiago de Compostela, Santiago de Compostela, Spain |
Cote : | Abonnement |
Lien : | http://dx.doi.org/10.1002/dta.2199 |
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