|Titre :||Unintentional cannabis intoxication in toddlers (2017)|
|Auteurs :||I. CLAUDET ; S. MOUVIER ; M. LABADIE ; C. MANIN ; A. P. MICHARD-LENOIR ; D. EYER ; D. DUFOUR ; MARIE-JEANNE STUDY GROUP|
|Type de document :||Article : Périodique|
|Dans :||Pediatrics (Vol.140, n°3, September 2017)|
|Article en page(s) :||e20170017 ; 11 p.|
|Discipline :||EPI (Epidémiologie / Epidemiology)|
Thésaurus TOXIBASEENFANT ; ETUDE RETROSPECTIVE ; CANNABIS ; INTOXICATION ; EVOLUTION ; ENFANT D'USAGER ; GEOGRAPHIE ; SYMPTOME ; COMPARAISON ; TETRAHYDROCANNABINOL ; COMA
BACKGROUND AND OBJECTIVES: In France, cannabis consumption is illegal. The health impact of its increasing use and higher tetrahydrocannabinol (THC) concentrations is still poorly documented, particularly that of unintentional pediatric intoxications. We sought to evaluate the French national trend of admissions for unintentional cannabis intoxication in children over an 11-year period (2004-2014).
METHODS: A retrospective, national, multicenter, observational study of a pediatric cohort. All children aged RESULTS: Twenty-four PEDs participated in our study; 235 children were included, and 71% of the patients were 18 months old or younger. Annual admissions increased by a factor of 13. Hashish resin was the main form ingested (72%). During the study period, the evolution was characterized by a national increase in intoxications, younger intoxicated children (1.28 ± 0.4 vs 1.7 ± 0.7 years, P = .005), and more comas (n = 38) (P = .05, odds ratio 3.5 [1.02-11.8]). Compared with other intoxications, other PED admissions, and the same age population, cannabis-related admissions were greater. There was a potential link between the increased incidence of comas and increased THC concentration in resin seized in France over the period.
CONCLUSIONS: Children are collateral victims of changing trends in cannabis use and a prevailing THC concentration. Intoxicated children are more frequent, are younger, and have intoxications that are more severe. This raises a real issue of public health.
|Domaine :||Drogues illicites / Illicit drugs|
|Refs biblio. :||44|
|Affiliation :||Service d'Accueil des Urgences Pédiatriques, Hôpital des Enfants, Centre Hospitalier Universitaire de Toulouse and Inserm, UMR 1027, Université Paul Sabatier Toulouse III, Toulouse, France|