Titre : | Six-year outcome of opioid maintenance treatment in heroin-dependent patients: Results from a naturalistic study in a nationally representative sample (2017) |
Auteurs : | M. SOYKA ; J. STREHLE ; J. REHM ; G. BUHRINGER ; H. U. WITTCHEN |
Type de document : | Article : Périodique |
Dans : | European Addiction Research (Vol.23, n°2, May 2017) |
Article en page(s) : | 97-105 |
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus géographique ALLEMAGNEThésaurus mots-clés ETUDE PROSPECTIVE ; TRAITEMENT DE MAINTENANCE ; HEROINE ; EPIDEMIOLOGIE ; METHADONE ; BUPRENORPHINE ; EFFICACITE ; ABSTINENCE ; RETENTION |
Résumé : |
BACKGROUND: In many countries, the opioid agonists, buprenorphine and methadone, are licensed for maintenance treatment of opioid dependence. Many short-term studies have been performed, but little is known about long-term effects. Therefore, this study described over 6 years (1) mortality, retention and abstinence rates and (2) changes in concomitant drug use and somatic and mental health.
METHODS: A prevalence sample of n = 2,694 maintenance patients, recruited from a nationally representative sample of n = 223 substitution doctors, was evaluated in a 6-year prospective-longitudinal naturalistic study. At 72 months, n = 1,624 patients were assessed for outcome; 1,147 had full outcome data, 346 primary outcome data and 131 had died; 660 individuals were lost to follow-up. RESULTS: The 6-year retention rate was 76.6%; the average mortality rate was 1.1%. During follow-up, 9.4% of patients became "abstinent" and 1.9% were referred for drug-free addiction treatment. Concomitant drug use decreased and somatic health status and social parameters improved. CONCLUSIONS: The study provides further evidence for the efficacy and safety of maintenance treatment with opioid agonists. In the long term, the number of opioid-free patients is low and most patients are more or less continuously under opioid maintenance therapy. Further implications are discussed. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 49 |
Affiliation : |
Medical Park Chiemseeblick, Bernau, Germany |
Cote : | Abonnement |
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