| Titre : | "NRG-3": What's in this? (2017) |
| Auteurs : | A. BATISSE ; M. MARILLIER ; C. CHEVALLIER ; E. BOURGOGNE ; M. GREGOIRE ; O. LAPREVOTE ; S. DJEZZAR |
| Type de document : | Article : Périodique |
| Dans : | Toxicologie Analytique et Clinique (Vol.29, n°1, Février 2017) |
| Article en page(s) : | 96-100 |
| Langues: | Anglais |
| Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
| Mots-clés : |
Thésaurus géographique FRANCEThésaurus mots-clés ETUDE DE CAS ; CATHINONES ; TOXICITE ; ANALYSE CHIMIQUE ; TOXICOLOGIE |
| Résumé : | The supply of recreational drugs has changed in the early 2000s and users increasingly buy cathinones over the Internet. There is a potential for significant toxicity associated with their use. Cathinone named "NRG-3" seems to be the most popular in Parisian CEIP data: the adverse events related to use of NRG-3 from 2011 to 2015 are reported. We aim at determining the chemical composition of NRG-3 available over the Internet and whether products differ depending on retailers. Three powders labelled "NRG-3" were purchased on July 2012 from three different Internet sites, moreover one capsule and one powder labelled "NRG-3" was given by drug users. These were analysed by LC–MSMS to determine active ingredients. The cathinones class was detected, without active adulterant. A great inconsistency in the qualitative and quantitative composition of products bearing identical labelling "NRG-3" was shown. We found two different single components: methylene dioxypyrovalerone (MDPV) and alpha-pyrrolidinopentiophenone (alpha-PVP) with mixture preparations in (3/5) samples. alpha-PVP varied from 4 to 80% and MDPV varied from 0 to 70%. There was significant variation of the products contained in NRG-3. This variation could be of clinical significance as the NRG-3 can be associated with worrisome toxicity. Marked agitation with violent and unpredictable acts is reported with MDPV: this molecule has a higher ability to cross the blood brain barrier because the pyrrolidine ring confers a low polarity. Given the plethora of NPS, proper drug identification is core essential for harm reduction associated with empowered users through education. |
| Domaine : | Drogues illicites / Illicit drugs |
| Sous-type de document : | Etude de cas / Case report |
| Refs biblio. : | 28 |
| Affiliation : | Center of evaluation, information on pharmacodependence and addictovigilance (CEIP-A), Fernand-Widal Hospital, Assistance publique-Hôpitaux de Paris, Paris, France |
| Cote : | Abonnement |
| Lien : | http://www.sciencedirect.com/science/journal/23520078/29/1 |
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