Titre : | Association between routes of drug administration and all-cause mortality among drug users (2016) |
Auteurs : | I. N. ONYEKA ; S. BASNETL ; C. M. BEYNON ; J. TIIHONEN ; J. FOHR ; J. KAUHANENL |
Type de document : | Article : Périodique |
Dans : | Journal of Substance Use (Vol.21, n°6, December 2016) |
Article en page(s) : | 559-565 |
Langues: | Anglais |
Discipline : | EPI (Epidémiologie / Epidemiology) |
Mots-clés : |
Thésaurus géographique FINLANDEThésaurus mots-clés PRODUIT ILLICITE ; MORTALITE ; VOIE D'ADMINISTRATION ; FACTEUR DE RISQUE ; CAUSE DE DECES |
Résumé : | Mortality among drug users based upon routes of administration (ROA) is less studied. We examined deaths by ROA, and association between ROA and all-cause deaths. Data of 2766 primary users of opiates and stimulants who sought treatment in Helsinki, Finland, from 1997 to 2008 were linked to the national cause-of-death register. Cox regression models were used to compute adjusted hazard ratios (aHRs) for all-cause deaths, with 95% confidence intervals (as). There were statistically significant differences in all-cause deaths by ROA reported at baseline interview (p = 0.012): 12.7% (n = 251/1976) among intravenous (IV) drug users, 11.5% (n = 27/235) among oral users, 7.9% (n = 12/152) among smokers, 6.9% (n = 19/276) among snorters, and 16.5% (n = 21/127) among those with unspecified ROA. IV users died more from accidental overdose relative to other specified routes (p = 0.036). All nine HIV and all three hepatitis C deaths occurred among IV users. The hazard for all-cause death was lower among smokers compared to IV users (aHR: 0.52 (95%CI: 0.28-0.97) after adjusting for gender, homelessness, drug use behaviours, and psychiatric comorbidities present at baseline. Deaths occurred in all groups: drug users in general need to be educated that no route of drug administration is harmless. Preventive and intervention measures should target all ROA. |
Domaine : | Drogues illicites / Illicit drugs |
Affiliation : | Institute of Public Health and Clinical Nutrition, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland |
Accueil