|Titre :||Changes in cannabis potency over the last 2 decades (1995-2014): Analysis of current data in the United States (2016)|
|Auteurs :||M. A. ElSOHLY ; Z. MEHMEDIC ; S. FOSTER ; C. GON ; S. CHANDRA ; J. C. CHURCH|
|Type de document :||Article : Périodique|
|Dans :||Biological Psychiatry (Vol.79, n°7, April 2016)|
|Article en page(s) :||613-619|
|Discipline :||PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)|
Thésaurus TOXIBASECANNABIS ; TETRAHYDROCANNABINOL ; EVOLUTION ; CANNABINOIDES ; ANALYSE CHIMIQUE ; PREVALENCE
BACKGROUND: Marijuana is the most widely used illicit drug in the United States and all over the world. Reports indicate that the potency of cannabis preparation has been increasing. This report examines the concentration of cannabinoids in illicit cannabis products seized by the U.S. Drug Enforcement Administration over the last 2 decades, with particular emphasis on Delta(9)-tetrahydrocannabinol and cannabidiol.
METHODS: Samples in this report were received over time from materials confiscated by the Drug Enforcement Administration and processed for analysis using a validated gas chromatography with flame ionization detector method.
RESULTS: Between January 1, 1995, and December 31, 2014, 38,681 samples of cannabis preparations were received and analyzed. The data showed that although the number of marijuana samples seized over the last 4 years has declined, the number of sinsemilla samples has increased. Overall, the potency of illicit cannabis plant material has consistently increased over time since 1995 from ~4% in 1995 to ~12% in 2014. The cannabidiol content has decreased on average from ~.28% in 2001 to <.15 in resulting a change the ratio of delta to cannabidiol from times> CONCLUSIONS: There is a shift in the production of illicit cannabis plant material from regular marijuana to sinsemilla. This increase in potency poses higher risk of cannabis use, particularly among adolescents.
|Domaine :||Drogues illicites / Illicit drugs|
|Refs biblio. :||10|
|Affiliation :||National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi, USA|