|Titre :||A novel approach to document single exposure to GHB: Hair analysis after sweat contamination [Letter] (2016)|
|Auteurs :||P. KINTZ|
|Type de document :||Article : Périodique|
|Dans :||Journal of Analytical Toxicology (Vol.40, n°7, September 2016)|
|Article en page(s) :||563-564|
|Discipline :||PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)|
Thésaurus TOXIBASEGHB ; ANALYSE CHIMIQUE ; PHANERES ; SUEUR ; CONTAMINATION
Although considered as a drug of abuse, gamma-hydroxybutyrate (GHB) is a substance naturally present within mammalian species and has been used clinically since the 1960s as an intravenous anesthetic. It was also investigated for treatment of insomnia, of alcohol and opiates withdrawal syndrome and in cerebrovascular disorders.
GHB is a white crystalline material. It is available as the sodium salt in the form of a white powder, capsules or tablets and also as a colorless, odorless liquid. It is taken orally and rarely injected.
Doses of 10 mg/kg cause amnesia, 20-30 mg/kg cause sleep and doses of 50 mg/kg or higher produce anesthesia. Illicit use of GHB typically involves doses of 35 mg/kg. GHB may be taken in doses of half to three teaspoons and produces drowsiness, euphoria, dizziness, amnesia and visual disturbances about 15 min later, lasting, on average, about 3 h.
People who may use GHB include bodybuilders who believe that the drug stimulates the release of growth hormone, even if it does affect or cause increased muscle mass or growth is still under debate; ravers or club attendees for its intoxicating effects such as euphoria, reduced inhibitions, sedation and muscle relaxation that can be beneficial after ecstasy abuse; drivers as a result of recreational abuse; and victims of drug-facilitated sexual assault. [Extract]
|Domaine :||Drogues illicites / Illicit drugs|
|Refs biblio. :||15|
|Affiliation :||X-Pertise Consulting, Oberhausbergen, France|