| Titre : | Report of five cases of 2,5-dimethoxy-4-(n)-propylphenethylamine (2C-P) intoxication following recreational use (2015) |
| Auteurs : | M. BRETAUDEAU DEGUIGNE ; S. FÉREC ; B. LELIÈVRE ; C. BRUNEAU ; B. DIQUET ; P. HARRY ; A. TURCANT |
| Type de document : | Article : Périodique |
| Dans : | Toxicologie Analytique et Clinique (Vol.27, n°2, Juin 2015) |
| Article en page(s) : | 99-104 |
| Langues: | Anglais |
| Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
| Mots-clés : |
Thésaurus Géographique FRANCEThésaurus TOXIBASE ETUDE DE CAS ; DROGUES DE SYNTHESE ; USAGE RECREATIF ; INTOXICATION ; TOXICOLOGIE ; ANALYSE CHIMIQUE |
| Résumé : |
Introduction: 2,5-dimethoxy-4-(n)-propylphenethylamine-P (2C-P) is a synthetic derivative belonging to the new so-called 2C-series family of phenethylamine recreational drugs. The exact mechanism of 2C compounds is unknown, but they show affinity for the 5-HT2 serotoninergic receptors. We report on the toxicological analysis findings on five cases of exposure to 2C-P.
Case-series: The five cases involved five men aged from 17 to 21 years old. They ingested 2C-P (powder or liquid form) in a festive setting. Their major symptoms were mydriasis, severe agitation, confusion, visual hallucinations, sinus tachycardia and high blood pressure. The outcome was favourable for the five patients. Methods: For the five patients, toxicological analyses of blood and urine samples obtained on admission were performed using both GC-MS and HPLC-DAD. Specific 2C-P assays were performed by HPLC-DAD and UPLC-MS/MS. Results: Toxicological analysis identified 2C-P as the main active substance in urines of all five cases and in the plasma of only one case (20 µg/L). Conclusion: Our results showed that 2C-P was active at very low levels. Clinicians should be alert to this substance and they should confirm exposure by blood and urine analysis. |
| Domaine : | Drogues illicites / Illicit drugs |
| Sous-type de document : | Etude de cas / Case report |
| Refs biblio. : | 19 |
| Affiliation : | Centre antipoison toxicovigilance Grand Ouest, CHU d'Angers, Angers, France |
| Cote : | Abonnement |
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