Titre : | Economic evaluation of Suboxone® for substitution treatment of opioid drug dependence in Portugal (2015) |
Auteurs : | M. GOUVEIA ; R. SOUSA ; J. COSTA ; M. BORGES |
Type de document : | Article : Périodique |
Dans : | Heroin Addiction and Related Clinical Problems (Vol.17, n°1, March 2015) |
Article en page(s) : | 43-50 |
Langues: | Anglais |
Discipline : | SAN (Santé publique / Public health) |
Mots-clés : |
Thésaurus géographique PORTUGALThésaurus mots-clés COUT ; EFFICACITE ; EVALUATION ; ECONOMIE ; PRODUIT DE SUBSTITUTION ; TRAITEMENT DE MAINTENANCE ; METHADONE ; OPIOIDES ; NALOXONE ; COMPARAISON ; QUALITE DE VIE ; HEROINE |
Mots-clés: | suboxone |
Résumé : |
Background: According to a recent Portuguese study the prevalence of lifetime consumption of heroin in the global population (age range: 15-74 years) is 0.5%. Methadone is the standard pharmacological treatment, while buprenorphine has been available since 1999 as an alternative treatment. Nevertheless, no comparative economic evaluation of the cost-effectiveness of these therapies has been made available.
Aim: This study estimates the cost-effectiveness and cost-utility of a fixed dose combination of buprenorphine-naloxone (B/N) versus methadone as substitution treatments for opioid drug dependence from the Portuguese social perspective. Material and Methods: The comparator for B/N was methadone treatment, which is the most common pharmacological therapy and current clinical practice in Portugal. Health gains were measured using the number of heroin-free days per year (indicator of effectiveness) and quality-adjusted life years (QALYs) associated with each treatment. Estimated costs included acquisition, preparation and transport of medication; costs of dispensing and supervision of administration; costs arising from the periodic monitoring of patients and the nonmedical direct costs of crime associated with drug addiction. Results: The B/N combination is associated with an incremental cost-utility ratio of €5,914 per QALY gained. The B/N combination is dominant when the analysis includes costs of crime associated with drug addiction. Conclusions: The results suggest that this combination is cost-effective and has the potential to generate health gains in the target population at a low cost. |
Domaine : | Autres substances / Other substances ; Drogues illicites / Illicit drugs |
Refs biblio. : | 38 |
Affiliation : | Católica Lisbon School of Business and Economics, Lisbon, Portugal |
Lien : | http://www.heroinaddictionrelatedclinicalproblems.org/harcp-archives.php |
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