Historique
Article de Périodique
Economic evaluation of Suboxone® for substitution treatment of opioid drug dependence in Portugal (2015)
Auteur(s) :
M. GOUVEIA ;
R. SOUSA ;
J. COSTA ;
M. BORGES
Article en page(s) :
43-50
Refs biblio. :
38
Domaine :
Autres substances / Other substances ; Drogues illicites / Illicit drugs
Langue(s) :
Anglais
Discipline :
SAN (Santé publique / Public health)
Thésaurus géographique
PORTUGAL
Thésaurus mots-clés
COUT
;
EFFICACITE
;
EVALUATION
;
ECONOMIE
;
PRODUIT DE SUBSTITUTION
;
TRAITEMENT DE MAINTENANCE
;
METHADONE
;
OPIOIDES
;
NALOXONE
;
COMPARAISON
;
QUALITE DE VIE
;
HEROINE
Autres mots-clés
Résumé :
Background: According to a recent Portuguese study the prevalence of lifetime consumption of heroin in the global population (age range: 15-74 years) is 0.5%. Methadone is the standard pharmacological treatment, while buprenorphine has been available since 1999 as an alternative treatment. Nevertheless, no comparative economic evaluation of the cost-effectiveness of these therapies has been made available.
Aim: This study estimates the cost-effectiveness and cost-utility of a fixed dose combination of buprenorphine-naloxone (B/N) versus methadone as substitution treatments for opioid drug dependence from the Portuguese social perspective.
Material and Methods: The comparator for B/N was methadone treatment, which is the most common pharmacological therapy and current clinical practice in Portugal. Health gains were measured using the number of heroin-free days per year (indicator of effectiveness) and quality-adjusted life years (QALYs) associated with each treatment. Estimated costs included acquisition, preparation and transport of medication; costs of dispensing and supervision of administration; costs arising from the periodic monitoring of patients and the nonmedical direct costs of crime associated with drug addiction.
Results: The B/N combination is associated with an incremental cost-utility ratio of €5,914 per QALY gained. The B/N combination is dominant when the analysis includes costs of crime associated with drug addiction.
Conclusions: The results suggest that this combination is cost-effective and has the potential to generate health gains in the target population at a low cost.
Aim: This study estimates the cost-effectiveness and cost-utility of a fixed dose combination of buprenorphine-naloxone (B/N) versus methadone as substitution treatments for opioid drug dependence from the Portuguese social perspective.
Material and Methods: The comparator for B/N was methadone treatment, which is the most common pharmacological therapy and current clinical practice in Portugal. Health gains were measured using the number of heroin-free days per year (indicator of effectiveness) and quality-adjusted life years (QALYs) associated with each treatment. Estimated costs included acquisition, preparation and transport of medication; costs of dispensing and supervision of administration; costs arising from the periodic monitoring of patients and the nonmedical direct costs of crime associated with drug addiction.
Results: The B/N combination is associated with an incremental cost-utility ratio of €5,914 per QALY gained. The B/N combination is dominant when the analysis includes costs of crime associated with drug addiction.
Conclusions: The results suggest that this combination is cost-effective and has the potential to generate health gains in the target population at a low cost.
Affiliation :
Católica Lisbon School of Business and Economics, Lisbon, Portugal