Historique
Article de Périodique
Methadone deaths in Scotland (2015)
Auteur(s) :
V. NIKOLAOU ;
J. LUTY
Article en page(s) :
17-22
Refs biblio. :
18
Domaine :
Autres substances / Other substances
Langue(s) :
Anglais
Discipline :
EPI (Epidémiologie / Epidemiology)
Thésaurus géographique
ECOSSE
;
ROYAUME-UNI
Thésaurus mots-clés
METHADONE
;
PRODUIT DE SUBSTITUTION
;
BUPRENORPHINE
;
MORTALITE
;
COUT
Résumé :
Aim: Identify factors which may be responsible for variations in methadone-related deaths in Scotland.
Method: Computer modelling based on data from drug-related deaths in Scotland in 2012 was used to predict the most effective combination of clinical parameters (methadone dose; supervision rates and provision of buprenorphine) that may predict how to reduce methadone-related deaths.
Results: Doubling the proportion of patients receiving buprenorphine (from 12% to 24%) would reduce the overall death rate by 18% (from 7.58 to 6.20 deaths per thousand problem drug users ~82 deaths).
This would cost an additional £2.52 million (£31 000 per life saved). Increasing the supervision rate for methadone from 57% to 67% would reduce the overall death rate by 0.68% (3 deaths ~£423 000 per life saved) while increasing the average daily dose of methadone from 90 mg to 100 mg would reduce the overall death rate by 2.5% (11 deaths ~£48 000 per life saved).
Conclusion: Greater use of buprenorphine products could significantly reduce methadone-related deaths.
Method: Computer modelling based on data from drug-related deaths in Scotland in 2012 was used to predict the most effective combination of clinical parameters (methadone dose; supervision rates and provision of buprenorphine) that may predict how to reduce methadone-related deaths.
Results: Doubling the proportion of patients receiving buprenorphine (from 12% to 24%) would reduce the overall death rate by 18% (from 7.58 to 6.20 deaths per thousand problem drug users ~82 deaths).
This would cost an additional £2.52 million (£31 000 per life saved). Increasing the supervision rate for methadone from 57% to 67% would reduce the overall death rate by 0.68% (3 deaths ~£423 000 per life saved) while increasing the average daily dose of methadone from 90 mg to 100 mg would reduce the overall death rate by 2.5% (11 deaths ~£48 000 per life saved).
Conclusion: Greater use of buprenorphine products could significantly reduce methadone-related deaths.
Affiliation :
NHS Borders, Scotland, Borders Addiction Service, Galashiels, Scotland, UK, EU