Titre : | Fatal intoxication with 3-methyl-N-methylcathinone (3-MMC) and 5-(2-aminopropyl)benzofuran (5-APB) (2014) |
Auteurs : | P. ADAMOWICZ ; D. ZUBA ; B. BYRSKA |
Type de document : | Article : Périodique |
Dans : | Forensic Science International (Vol.245, December 2014) |
Article en page(s) : | 126-132 |
Langues: | Anglais |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus géographique POLOGNEThésaurus mots-clés ETUDE DE CAS ; INTOXICATION ; MORTALITE ; DROGUES DE SYNTHESE ; TOXICOLOGIE ; SYMPTOME ; ANALYSE CHIMIQUE |
Résumé : |
The emergence of a large number of new psychoactive substances (NPSs) in recent years poses a serious problem to clinical and forensic toxicologists. Here we report a patient who administrated ca. 500 mg of 3-MMC (3-methyl-N-methylcathinone) and 400 mg of 5-APB (5-(2-aminopropyl)benzofuran) in combination with 80 g of ethyl alcohol. The clinical manifestations included agitation, seizures, hypertension, tachycardia, hyperthermia and bradycardia. The patient did not recover and died around 4 h after the use of drugs. The cause of death was acute cardiovascular collapse that occurred following mixed intoxication with NPSs and alcohol. Toxicological analysis of post-mortem blood revealed 3-MMC and 5-APB in concentrations of 1.6 μg/mL and 5.6 μg/mL, respectively. Moreover, the serum alcohol concentration was 1.4 g/L in ante-mortem sample collected 1 h after admission to the hospital. This is the first report on blood concentration of 3-MMC and 5-APB in fatal intoxication.
Highlights: We report a fatal case of 3-MMC and 5-APB poisoning in combination with alcohol. The clinical manifestations included agitation, seizures, hypertension, tachycardia, hyperthermia and bradycardia. Results of toxicological analysis were as follows: 1.6 μg/mL for 3-MMC, 5.6 μg/mL for 5-APB and 1.4 g/L for alcohol. Developed methods allow distinguishing between 3-MMC and 4-MMC as well as 5-APB and 6-ABP. |
Domaine : | Drogues illicites / Illicit drugs |
Sous-type de document : | Etude de cas / Case report |
Refs biblio. : | 39 |
Affiliation : | Institute of Forensic Research, Krakow, Poland |
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