Historique
Article de Périodique
AKI associated with synthetic cannabinoids: a case series (2013)
Auteur(s) :
G. K. BHANUSHALI ;
G. JAIN ;
H. FATIMA ;
L. J. LEISCH ;
D. THORNLEY-BROWN
Article en page(s) :
523-526
Sous-type de document :
Etude de cas / Case report
Refs biblio. :
9
Domaine :
Drogues illicites / Illicit drugs
Langue(s) :
Anglais
Discipline :
PAT (Pathologie organique / Organic pathology)
Thésaurus mots-clés
ETUDE DE CAS
;
REIN
;
CANNABINOIDES
;
DROGUES DE SYNTHESE
;
PATHOLOGIE ORGANIQUE
;
NEPHROLOGIE
;
NEPHROPATHIE
Thésaurus géographique
ETATS-UNIS
Note générale :
AKI = Acute kidney injury
Résumé :
SPICE, or K2, encompasses preparations of synthetic cannabinoids marketed as incense products, bath additives, and air fresheners and used for recreational purposes. These preparations are usually smoked for their cannabis-like effects and do not appear on routine urine toxicology screens. We report four cases of oliguric AKI associated with SPICE use in previously healthy men. All showed improvement in renal function without need for renal replacement therapy. Renal biopsy, performed in three of the patients, revealed acute tubular necrosis. The close temporal and geographic associations between the clinical presentation and the development of AKI strongly suggest an association between these SPICE preparations and AKI. Further investigations are required to identify the potential nephrotoxic agent(s). Nephrotoxicity from designer drugs should be included in the differential diagnosis of AKI, especially in young adults with negative urine drug screens.
Affiliation :
Division of Nephrology, Department of Internal Medicine, University of Alabama, Birmingham, AL 35294-0007, USA