|Titre :||Treatment retention among patients randomized to buprenorphine/naloxone compared to methadone in a multi-site trial (2014)|
|Auteurs :||Y. I. HSER ; A. J. SAXON ; D. HUANG ; A. HASSON ; C. THOMAS ; M. HILLHOUSE ; P. JACOBS ; C. TERUYA ; P. McLAUGHLIN ; K. WIEST ; A. COHEN ; W. LING|
|Type de document :||Article : Périodique|
|Dans :||Addiction (Vol.109, n°1, January 2014)|
|Article en page(s) :||79-87|
|Note générale :||Commentary: To retain or not to retain - open questions in opioid maintenance therapy. Soyka M., Hillemacher T., p. 88-89.|
|Discipline :||TRA (Traitement et prise en charge / Treatment and care)|
Thésaurus TOXIBASECOMPARAISON ; TRAITEMENT DE MAINTENANCE ; BUPRENORPHINE ; NALOXONE ; METHADONE ; PRODUIT DE SUBSTITUTION ; OBSERVANCE DU TRAITEMENT ; ETUDE RANDOMISEE ; ETUDE CLINIQUE
Aims: To examine patient and medication characteristics associated with retention and continued illicit opioid use in methadone (MET) versus buprenorphine/naloxone (BUP) treatment for opioid dependence.
Design, settings and participants: This secondary analysis included 1267 opioid-dependent individuals participating in nine opioid treatment programs between 2006 and 2009 and randomized to receive open-label BUP or MET for 24 weeks.
Measurements: The analyses included measures of patient characteristics at baseline (demographics; use of alcohol, cigarettes and illicit drugs; self-rated mental and physical health), medication dose and urine drug screens during treatment, and treatment completion and days in treatment during the 24-week trial.
Findings: The treatment completion rate was 74% for MET versus 46% for BUP (P Conclusions: Provision of methadone appears to be associated with better retention in treatment for opioid dependence than buprenorphine, as does use of provision of higher doses of both medications. Provision of buprenorphine is associated with lower continued use of illicit opioids.
Treatment with methadone appears to be associated with better retention in treatment for opioid dependence than buprenorphine, as does higher doses of both medications. Treatment with buprenorphine is associated with lower continued use of illicit opioids.
|Domaine :||Drogues illicites / Illicit drugs|
|Refs biblio. :||35|
|Affiliation :||University of California, Los Angeles, CA, USA|