|Titre :||Change in cannabis use, clinical symptoms and social functioning among patients with first-episode psychosis: a 5-year follow-up study of patients in the OPUS trial (2014)|
|Auteurs :||L. CLAUSEN ; C. R. HJORTHOJ ; A. THORUP ; P. JEPPESEN ; L. PETERSEN ; M. BERTELSEN ; NORDENTOFT M.|
|Type de document :||Article : Périodique|
|Dans :||Psychological Medicine (Vol.44, n°1, January 2014)|
|Article en page(s) :||117-126|
|Discipline :||PSY (Psychopathologie / Psychopathology)|
Thésaurus TOXIBASECANNABIS ; TROUBLE BIPOLAIRE ; ETUDE CLINIQUE ; PSYCHOSE ; SCHIZOPHRENIE ; SUIVI DU PATIENT ; TYPE D'USAGE
BACKGROUND: Several studies indicate that cannabis use among patients with psychotic disorders is associated with worse outcome, but only a few studies have controlled for baseline condition and medication. Method At 5-year follow-up, interviews were carried out with 314 first-episode psychosis patients included in the OPUS trial. The patients included were in the age range of 18 to 45 years old and 59% were male. Cannabis use was extracted from the Schedule for Clinical Assessment in Neuropsychiatry. At follow-up, the patients were divided into different groups according to the variable cannabis use: abstainers, stoppers, starters and continuers. Psychotic, negative and disorganized dimensions (ranging from zero to five) were calculated for each of the four groups based on the Schedule for the Assessment of Positive and Negative Symptoms in Schizophrenia.
RESULTS: Cannabis users were younger (24.6 years v. 27.4 years, p CONCLUSIONS: Continuous cannabis use was associated with higher levels of psychotic symptoms after 5 years, and this association was only partly explained by insufficient antipsychotic medication.
|Domaine :||Drogues illicites / Illicit drugs|
|Affiliation :||Psychiatric Center Copenhagen, Copenhagen University, Faculty of Health Sciences, Copenhagen, Denmark|