| Titre : | Prevalence of hepatitis B and hepatitis C virus infections in France in 2004: social factors are important predictors after adjusting for known risk factors (2010) |
| Auteurs : | C. MEFFRE ; Y. LE STRAT ; E. DELAROCQUE-ASTAGNEAU ; F. DUBOIS ; D. ANTONA ; J. M. LEMASSON ; J. WARSZAWSKI ; J. STEINMETZ ; D. COSTE ; J. F. MEYER ; S. LEISER ; J. P. GIORDANELLA ; R. GUEGUEN ; J. C. DESENCLOS |
| Type de document : | Article : Périodique |
| Dans : | Journal of Medical Virology (Vol.82, n°4, April 2010) |
| Article en page(s) : | 546-555 |
| Langues: | Anglais |
| Discipline : | MAL (Maladies infectieuses / Infectious diseases) |
| Mots-clés : |
Thésaurus TOXIBASE HEPATITE ; PREVALENCE ; INFECTION ; FACTEUR DE RISQUE ; ETUDE TRANSVERSALE ; FACTEUR PREDICTIF ; ANALYSE CHIMIQUE ; TEST ; INJECTIONThésaurus Géographique FRANCE |
| Résumé : | To monitor the prevalence of hepatitis B and hepatitis C a cross-sectional survey was conducted in 2004 among French metropolitan residents. A complex sampling design was used to enroll 14,416 adult participants aged 18-80 years. Data collected included demographic and social characteristics and risk factors. Sera were tested for anti-HCV, HCV-RNA, anti-HBc and HBsAg. Data were analyzed with SUDAAN software to provide weighted estimates for the French metropolitan resident population. The overall anti-HCV prevalence was 0.84% (95% CI: 0.65-1.10). Among anti-HCV positive individuals, 57.4% (95% CI: 43.2-70.5) knew their status. Factors associated independently with positive anti-HCV were drug use (intravenous and nasal), blood transfusion before 1992, a history of tattoos, low socioeconomic status, being born in a country where anti-HCV prevalence >2.5%, and age >29 years. The overall anti-HBc prevalence was 7.3% (95%: 6.5-8.2). Independent risk factors for anti-HBc were intravenous drug use, being a man who has sex with men, low socioeconomic status, a stay in a psychiatric facility or facility for the mentally disabled, 2%, age >29 and male sex. The HCV RNA and HBsAg prevalence were 0.53% (95% CI: 0.40-0.70) and 0.65% (95% CI: 0.45-0.93), respectively. Among HBsAg positive individuals, 44.8% (95% CI: 22.8-69.1) knew their status. Anti-HCV prevalence was close to the 1990s estimates whereas HBsAg prevalence estimate was greater than expected. Screening of hepatitis B and C should be strengthened and should account for social vulnerability. |
| Domaine : | Drogues illicites / Illicit drugs |
| Affiliation : | National Institute for Public Health Surveillance (InVS), Saint-Maurice, France |
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