Historique
Article de Périodique
Epidemiological changes in hepatitis C virus genotypes in France: evidence in intravenous drug users (2002)
Auteur(s) :
BOURLIÈRE, M. ;
BARBERIN, J. M. ;
ROTILY, M. ;
GUAGLIARDO, V. ;
PORTAL, I. ;
LECOMTE, L. ;
BENALI, S. ;
BOUSTIÈRE, C. ;
PERRIER, H. ;
JULLIEN, M. ;
LAMBOT, G. ;
LOYER, R. ;
LEBARS, O. ;
DANIEL, R. ;
KHIRI, H. ;
HALFON, P.
Année :
2002
Page(s) :
62-70
Langue(s) :
Anglais
Refs biblio. :
44
Domaine :
Drogues illicites / Illicit drugs
Discipline :
MAL (Maladies infectieuses / Infectious diseases)
Thésaurus géographique
FRANCE
Thésaurus mots-clés
HEPATITE
;
EPIDEMIOLOGIE DESCRIPTIVE
;
GENETIQUE
;
USAGER
;
INFECTION
;
GEOGRAPHIE
;
ETUDE CLINIQUE
;
CONTAMINATION
Résumé :
Hepatitis C virus (HCV) genotypes are distributed differently depending on geography and route of infection. We characterized the distribution of genotypes in a large cohort of patients with chronic hepatitis C in the South-east of France and evaluated the relative prevalence according to time of acquisition. One thousand, one hundred-and-eighty-three patients who were anti-HCV-positive were studied. HCV genotype distribution has changed significantly from the 1960s to 2000. The prevalence of genotype 1b decreased from 47% before 1978 to 18.8% in the 1990s while the prevalence of genotype 1a and 3a increased during the same period from 18% and 15.3% to 28.8% and 26.3%, respectively. The logistic regression model showed that genotype 1a was significantly more common in patients infected through intravenous drug injection odds ratio ((OR): 2.08, P
Affiliation :
Department of Gastroenterology and Liver Unit, Hôpital Saint Joseph, France