Titre : | Epidemiological changes in hepatitis C virus genotypes in France: evidence in intravenous drug users (2002) |
Auteurs : | M. BOURLIÈRE ; J. M. BARBERIN ; M. ROTILY ; V. GUAGLIARDO ; I. PORTAL ; L. LECOMTE ; S. BENALI ; C. BOUSTIÈRE ; H. PERRIER ; M. JULLIEN ; G. LAMBOT ; R. LOYER ; O. LEBARS ; R. DANIEL ; H. KHIRI ; P. HALFON |
Type de document : | Article : Périodique |
Dans : | Journal of Viral Hepatitis (Vol.9, n°1, January 2002) |
Article en page(s) : | 62-70 |
Langues: | Anglais |
Discipline : | MAL (Maladies infectieuses / Infectious diseases) |
Mots-clés : |
Thésaurus géographique FRANCEThésaurus mots-clés HEPATITE ; EPIDEMIOLOGIE DESCRIPTIVE ; GENETIQUE ; USAGER ; INFECTION ; GEOGRAPHIE ; ETUDE CLINIQUE ; CONTAMINATION |
Résumé : | Hepatitis C virus (HCV) genotypes are distributed differently depending on geography and route of infection. We characterized the distribution of genotypes in a large cohort of patients with chronic hepatitis C in the South-east of France and evaluated the relative prevalence according to time of acquisition. One thousand, one hundred-and-eighty-three patients who were anti-HCV-positive were studied. HCV genotype distribution has changed significantly from the 1960s to 2000. The prevalence of genotype 1b decreased from 47% before 1978 to 18.8% in the 1990s while the prevalence of genotype 1a and 3a increased during the same period from 18% and 15.3% to 28.8% and 26.3%, respectively. The logistic regression model showed that genotype 1a was significantly more common in patients infected through intravenous drug injection odds ratio ((OR): 2.08, P |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 44 |
Affiliation : | Department of Gastroenterology and Liver Unit, Hôpital Saint Joseph, France |
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