Titre : | Synthetic cannabinoids in "spice-like" herbal blends: First appearance of JWH-307 and recurrence of JWH-018 on the German market (2012) |
Auteurs : | L. ERNST ; K. KRÜGER ; R. LINDIGKEIT ; H. M. SCHIEBEL ; T. BEUERLE |
Type de document : | Article : Périodique |
Dans : | Forensic Science International (Vol.222, n°1-3, 10 October 2012) |
Article en page(s) : | 216-222 |
Langues: | Anglais |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus géographique ALLEMAGNEThésaurus mots-clés CANNABINOIDES ; DROGUES DE SYNTHESE ; MARCHE DE LA DROGUE ; ANALYSE CHIMIQUE ; CHIMIE |
Résumé : |
Herbal smoking blends, available on the German market were analyzed and several known synthetic cannabinoids were identified (JWH-122 and JWH-018).
In addition, we isolated a new active ingredient by silica gel column chromatography and elucidated the structure by nuclear magnetic resonance (NMR) methods. The compound was identified as JWH-307, a synthetic cannabinoid of the phenyl-pyrrole subclass with known in vitro binding affinities for cannabinoid receptors. To date, this is the first appearance of this subclass of cannabimimetics in such products. JWH-307 has been further characterized by gas chromatography accurate mass spectrometry (GC–HRMS), electrospray tandem mass spectrometry (ESI-MS/MS), ultraviolet (UV) and infrared (IR) spectroscopy. JWH-018 was among the first compounds banned by many countries world-wide including Germany. The identification of JWH-018 was striking, since this is the first report where JWH-018 recurred on the German market thus violating existing laws. A generic method was established to quantify synthetic cannabinoids in herbal smoking blends. Quantification was achieved using an isotopically labeled standard (JWH-018-D3). JWH-018 was found at a level of 150 mg/g while JWH-122 and JWH-307 occurred as a mixture at a total level of 232 mg/g. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 21 |
Affiliation : | Chemistry Department, Central NMR Laboratory, Technische Universität Braunschweig, Braunschweig, Germany |
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