Titre : | A case-control study estimating accident risk for alcohol, medicines and illegal drugs (2012) |
Auteurs : | K. P. KUYPERS ; S. A. LEGRAND ; J. G. RAMAEKERS ; A. G. VERSTRAETE |
Type de document : | Article : Périodique |
Dans : | PLOS ONE (Vol.7, n°8, August 2012) |
Article en page(s) : | e43496 ; 9 p. |
Langues: | Anglais |
Discipline : | EPI (Epidémiologie / Epidemiology) |
Mots-clés : |
Thésaurus géographique BELGIQUEThésaurus mots-clés CONDUITE DE VEHICULE ; ACCIDENT ; ETUDE CAS-TEMOINS ; FACTEUR DE RISQUE ; ALCOOL ; MEDICAMENTS ; PRODUIT ILLICITE ; DEPISTAGE ; SANG ; TETRAHYDROCANNABINOL ; CANNABIS ; PSYCHOTROPES ; POLYCONSOMMATION |
Résumé : |
FRANÇAIS :
Cette étude a montré qu'une concentration sanguine de 2 ng/ml de THC est associée avec un risque d'accident 4 fois supérieur par rapport à des concentrations de THC plus faibles. Les scientifiques ont comparé 337 sujets impliqués dans des accidents, dont 161 avaient consommé de l'alcool et/ou un stupéfiant. Ils avaient été sélectionnés parmi une base de 2726 conducteurs pris au hasard, et dont 301 avaient consommé de l'alcool ou un stupéfiant. Les scientifiques ont conclu : "l'étude montre que la concentration de THC est liée au risque d'accident. L'alcool et la combinaison alcool/drogue sont les substances les plus répandues parmi les conducteurs, ce qui amène un plus grand risque, tant du point de vue du nombre que de l'ampleur." [Résumé IACM] ENGLISH: BACKGROUND: The aim of the present study was to assess the risk of having a traffic accident after using alcohol, single drugs, or a combination, and to determine the concentrations at which this risk is significantly increased. METHODS: A population-based case-control study was carried out, collecting whole blood samples of both cases and controls, in which a number of drugs were detected. The risk of having an accident when under the influence of drugs was estimated using logistic regression adjusting for gender, age and time period of accident (cases)/sampling (controls). The main outcome measures were odds ratio (OR) for accident risk associated with single and multiple drug use. In total, 337 cases (negative: 176; positive: 161) and 2726 controls (negative: 2425; positive: 301) were included in the study. RESULTS: Main findings were that 1) alcohol in general (all the concentrations together) caused an elevated crash risk; 2) cannabis in general also caused an increase in accident risk; at a cut-off of 2 ng/mL THC the risk of having an accident was four times the risk associated with the lowest THC concentrations; 3) when ranking the adjusted OR from lowest to highest risk, alcohol alone or in combination with other drugs was related to a very elevated crash risk, with the highest risk for stimulants combined with sedatives. CONCLUSION: The study demonstrated a concentration-dependent crash risk for THC positive drivers. Alcohol and alcohol-drug combinations are by far the most prevalent substances in drivers and subsequently pose the largest risk in traffic, both in terms of risk and scope. |
Domaine : | Alcool / Alcohol ; Autres substances / Other substances ; Drogues illicites / Illicit drugs |
Refs biblio. : | 31 |
Affiliation : | Department of Neuropsychology & Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands |
Lien : | http://dx.doi.org/10.1371/journal.pone.0043496 |
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