Titre : | Designer drugs in herbal aphrodisiacs (2008) |
Auteurs : | B. J. VENHUIS ; L. BLOK-TIP ; D. DE KASTE |
Type de document : | Article : Périodique |
Dans : | Forensic Science International (Vol.177, n°2–3, 20 May 2008) |
Article en page(s) : | e25-e27 |
Langues: | Anglais |
Discipline : | MAR (Marchés / Markets) |
Mots-clés : |
Thésaurus mots-clés DROGUES DE SYNTHESE ; PLANTES ; ANALYSE CHIMIQUE ; SILDENAFIL ; PSYCHOTROPES |
Résumé : | In the presented case three herbal aphrodisiacs (Libidfit, Satibo and Viamax) were investigated for the presence of regular pharmaceuticals against erectile dysfunction. However, high-performance liquid chromatography with diode array detection and mass spectrometry (HPLC-DAD–MS) and nuclear magnetic resonance (NMR) analyses revealed the presence of ingredients, having a molecular structure strongly resembling those of sildenafil (Viagra) and vardenafil (Levitra). The health risk posed by these analogous substances is high because they were found to be potent phosphodiesterase 5 (PDE5) inhibitors used in pharmacologically relevant quantities having no known safety profile. Based on structural and functional analogy these analogs represent a new class of designer drugs and should be taken off the market for being unapproved drug substances. In the Libidfit court case this was done successfully, setting a precedent. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 24 |
Affiliation : | RIVM - National Institute for Public Health and the Environment, PO Box 1, NL-3720 BA Bilthoven, Pays-Bas |
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