|Titre :||Cognitive and subjective effects of mephedrone and factors influencing use of a 'new legal high' (2012)|
|Auteurs :||T. P. FREEMAN ; C. J. A. MORGAN ; J. VAUGHN-JONES ; N. HUSSAIN ; K. KARIMI ; H. V. CURRAN|
|Type de document :||Article : Périodique|
|Dans :||Addiction (Vol.107, n°4, April 2012)|
|Article en page(s) :||792-800|
|Discipline :||PSY (Psychopathologie / Psychopathology)|
Thésaurus TOXIBASEMEPHEDRONE ; EFFET SECONDAIRE ; COGNITION ; BIEN-ETRE ; ATTITUDE ; DROGUES DE SYNTHESE ; ETUDE CAS-TEMOINS
Aims - Use of the stimulant drug mephedrone increased dramatically in 2009, and it is still available in the United Kingdom after being controlled in April 2010. This study aimed to assess mephedrone's acute cognitive and subjective effects.
Design - A mixed within- and between-subjects design compared 20 mephedrone users, first while intoxicated (T1) and secondly drug free (T2); and 20 controls twice when drug free (T1 and T2).
Settings - Participants' own homes.
Participants - Healthy adults recruited from the community.
Measurements - Subjective effects, episodic and working memory, phonological and semantic fluency, psychomotor speed and executive control at were assessed at T1 and T2. Trait schizotypy, depression, changes in mephedrone use since the ban and attitudes influencing use of a hypothetical new legal high were indexed at T2 only.
Findings - Compared with controls, mephedrone users had generally impaired prose recall (P = 0.037) and higher scores in schizotypy (P Conclusions - Mephedrone impairs working memory acutely, induces stimulant-like effects in users and is associated with binge use. Factors that influence users' attitudes to new drugs might help to predict future trends in use of the many new psychoactive substances emerging on the internet.
|Domaine :||Drogues illicites / Illicit drugs|
|Refs biblio. :||25|
|Affiliation :||Clinical Psychopharmacology Unit, Clinical Health Psychology, University College London, London, UK|