|Titre :||Impact of in-patient research participation on subsequent heroin use patterns: implications for ethics and public health (2012)|
|Auteurs :||P. ROUX ; C. TINDALL ; L. FUGON ; J. MURRAY ; S. K. VOSBURG ; P. SACCONE ; M. A. SULLIVAN ; J. M. MANUBAY ; Z. D. COOPER ; J. D. JONES ; R. W. FOLTIN ; S. D. COMER|
|Type de document :||Article : Périodique|
|Dans :||Addiction (Vol.107, n°3, March 2012)|
|Article en page(s) :||642-649|
|Discipline :||TRA (Traitement et prise en charge / Treatment and care)|
Thésaurus TOXIBASERECHERCHE ; ETHIQUE ; HEROINE ; TRAITEMENT DE MAINTENANCE ; ABSTINENCE ; SUIVI DU PATIENT
Aims: Research on drug dependence often involves the administration of drugs of abuse to experienced drug users under controlled laboratory conditions. The primary objective of this study was to assess whether participation in such research alters the frequency of heroin use by non-treatment-seeking opioid-dependent volunteers after study completion.
Design: Data were examined from four in-patient studies involving controlled opioid administration.
Setting: Substance Use Research Center at Columbia University, New York State Psychiatric Institute.
Participants: Sixty-nine heroin-dependent volunteers.
Measurements: Participants' self-reported heroin use prior to and 1 month after study participation was compared using a Wilcoxon test. Because a number of participants reported that they had stopped using heroin, a logistic regression was used to identify correlates of heroin cessation 1 month after study completion.
Findings: One hundred and one participants entered laboratory studies and 69 completed them. Self-reported heroin use significantly decreased 1 month after study participation [ 1.7 (±2.0) bags per day] compared to baseline [6.8 (±4.2) bags per day], P Conclusions: Participation in opioid administration studies does not increase subsequent heroin use and for some individuals leads to accessing opioid dependence treatment and cessation of heroin use in the short term.
|Domaine :||Drogues illicites / Illicit drugs|
|Refs biblio. :||30|
|Affiliation :||Substance Use Research Center, NYSPI, Columbia University, New York, NY, USA ; INSERM, U912 (SE4S), Marseille, France|