|Titre :||Association between marijuana exposure and pulmonary function over 20 years (2012)|
|Auteurs :||M. J. PLETCHER ; E. VITTINGHOFF ; R. KALHAN ; J. RICHMAN ; M. SAFFORD ; S. SIDNEY ; F. LIN ; S. KERTESZ|
|Type de document :||Article : Périodique|
|Dans :||Journal of the American Medical Association (Vol.307, n°2, January 11, 2012)|
|Article en page(s) :||173-181|
|Note générale :||
- Letter: "Long-term marijuana use and pulmonary function", R.B. Patel, N. Khazeni, JAMA 2012;307(17):1796.
- Authors' reply: JAMA 2012;307(17):1796-1797.
|Discipline :||PAT (Pathologie organique / Organic pathology)|
Thésaurus TOXIBASEETUDE LONGITUDINALE ; ADULTE JEUNE ; CANNABIS ; POUMON ; APPAREIL RESPIRATOIRE ; TABAC ; TYPE D'USAGE
CONTEXT: Marijuana smoke contains many of the same constituents as tobacco smoke, but whether it has similar adverse effects on pulmonary function is unclear.
OBJECTIVE: To analyze associations between marijuana (both current and lifetime exposure) and pulmonary function.
DESIGN, SETTING, AND PARTICIPANTS: The Coronary Artery Risk Development in Young Adults (CARDIA) study, a longitudinal study collecting repeated measurements of pulmonary function and smoking over 20 years (March 26, 1985-August 19, 2006) in a cohort of 5115 men and women in 4 US cities. Mixed linear modeling was used to account for individual age-based trajectories of pulmonary function and other covariates including tobacco use, which was analyzed in parallel as a positive control. Lifetime exposure to marijuana joints was expressed in joint-years, with 1 joint-year of exposure equivalent to smoking 365 joints or filled pipe bowls.
MAIN OUTCOME MEASURES: Forced expiratory volume in the first second of expiration (FEV1) and forced vital capacity (FVC).Results Marijuana exposure was nearly as common as tobacco exposure but was mostly light (median, 2-3 episodes per month). Tobacco exposure, both current and lifetime, was linearly associated with lower FEV1 and FVC. In contrast, the association between marijuana exposure and pulmonary function was nonlinear (P CONCLUSION: Occasional and low cumulative marijuana use was not associated with adverse effects on pulmonary function.
|Domaine :||Drogues illicites / Illicit drugs|
|Refs biblio. :||36|
|Affiliation :||Department of Epidemiology and Biostatistics and Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, USA|