|Titre :||Mephedrone: use, subjective effects and health risks (2011)|
|Titre original:||(Méphédrone : usage, effets subjectifs et risques pour la santé)|
|Auteurs :||A. WINSTOCK ; L. MITCHESON ; J. RAMSEY ; S. DAVIES ; M. PUCHNAREWICZ ; J. MARSDEN|
|Type de document :||Article : Périodique|
|Dans :||Addiction (Vol.106, n°11, November 2011)|
|Article en page(s) :||1991-1996|
|Discipline :||PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)|
Thésaurus TOXIBASEMEPHEDRONE ; ETUDE TRANSVERSALE ; TELEPHONE ; ENQUETE ; TOXICOLOGIE ; EFFET SECONDAIRE ; CONSOMMATION ; PREVALENCE ; DEPENDANCE
AIMS To assess the patterns of use, subjective effect profile and dependence liability of mephedrone, supported by corroborative urine toxicology.
DESIGN Cross-sectional structured telephone interview. Setting UK-based drug users associated with the dance music scene.
PARTICIPANTS A total of 100 mephedrone users, recruited through their involvement with the dance music scene.
MEASUREMENTS Assessment of pattern of use, acute and after effects, DSM dependence criteria and gas chromatography-mass spectrometry urinalysis.
FINDINGS Mephedrone consumption results in typical stimulant-related subjective effects: euphoria, increased concentration, talkativeness, urge to move, empathy, jaw clenching, reduced appetite and insomnia. Thirty per cent of the sample potentially met criteria for DSM-IV dependence and there was evidence of a strong compulsion to use the drug (47% had used the drug for 2 or more consecutive days). Self-reported recent consumption of mephedrone was confirmed by toxicological analysis in all of the 14 participants who submitted a urine sample.
CONCLUSION Mephedrone has a high abuse and health risk liability, with increased tolerance, impaired control and a compulsion to use, the predominant reported dependence symptoms.
|Domaine :||Drogues illicites / Illicit drugs|
|Refs biblio. :||13|
|Affiliation :||Addictions Department, Institute of Psychiatry, King's College London, United Kingom|