Titre : | Separate and combined effects of the cannabinoid agonists nabilone and delta(9)-THC in humans discriminating delta(9)-THC (2011) |
Titre traduit : | (Effets séparés et combinés des agonistes cannabinoïdes nabilone et delta(9)-THC chez des humains capable de discriminer le delta(9)-THC) |
Auteurs : | J. A. LILE ; T. H. KELLY ; L. R. HAYS |
Type de document : | Article : Périodique |
Dans : | Drug and Alcohol Dependence (Vol.116, n°1-3, July 2011) |
Article en page(s) : | 86-92 |
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés CANNABINOIDES ; CANNABIS ; DEPENDANCE ; AGONISTE ; TRAITEMENT DE MAINTENANCE ; ETUDE DE CAS ; MESURES QUANTITATIVES ; EFFET SECONDAIRE |
Résumé : | BACKGROUND: Agonist replacement treatment is a promising strategy to manage cannabis-use disorders. The aim of this study was to assess the combined effects of the synthetic cannabinoid agonist nabilone and Delta(9)-tetrahydrocannabinol (Delta(9)-THC) using drug-discrimination procedures, which are sensitive to drug interactions. Testing the concurrent administration of nabilone and Delta(9)-THC was also conducted to provide initial safety and tolerability data, which is important because cannabis users will likely lapse during treatment. METHODS: Six cannabis users learned to discriminate 30mg oral Delta(9)-THC from placebo and then received nabilone (0, 1 and 3mg) and Delta(9)-THC (0, 5, 15 and 30mg), alone and in combination. Subjects completed the multiple-choice procedure to assess drug reinforcement, and self-report, task performance and physiological measures were collected. RESULTS: Delta(9)-THC and nabilone alone shared discriminative-stimulus effects with the training dose of Delta(9)-THC, increased crossover point on the multiple-choice procedure, produced overlapping subject ratings and decreased skin temperature. Nabilone alone also elevated heart rate. In combination, nabilone shifted the discriminative-stimulus effects of Delta(9)-THC leftward/upward and enhanced Delta(9)-THC effects on the other outcome measures. CONCLUSIONS: These results replicate a previous study demonstrating that nabilone shares agonist effects with the active constituent of cannabis in cannabis users, and contribute further by indicating that nabilone would likely be safe and well tolerated when combined with cannabis. These data support the conduct of future studies to determine if nabilone treatment would produce cross-tolerance to the abuse-related effects of cannabis and reduce cannabis use. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 51 |
Affiliation : |
Department of Behavioral Science, University of Kentucky College of Medicine, College of Medicine Office Building, Lexington, KY 40536-0086, Etats-Unis. United States. |
Accueil