Titre : | Proficiency testing (external quality assessment) of drug detection in oral fluid (2005) |
Auteurs : | J. CLARKE ; J. F. WILSON |
Type de document : | Article : Périodique |
Dans : | Forensic Science International (Vol.150, n°2-3, 10 June 2005) |
Article en page(s) : | 161-164 |
Langues: | Anglais |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus mots-clés TEST ; SENSIBILITE ; SALIVE ; DEPISTAGE ; AMPHETAMINES ; CANNABIS ; OPIACES ; METHODE ; PSYCHOTROPES ; ANALYSE CHIMIQUE |
Résumé : | Eighteen external quality assessment (proficiency testing) samples were prepared from client specimens collected with the Intercept oral fluid collection device and by spiking drug-free oral fluid. Samples were circulated in pairs at quarterly intervals to 13 UK and USA based laboratories for analysis by a panel of OraSure micro-plate Intercept enzyme immunoassay kits and hyphenated mass spectrophotometric techniques. During the survey, there was a single case of non-specificity in a false report for methadone. The major errors were of lack of sensitivity relative to the concentration thresholds specified for the immunoassays. The sensitivity for overall "present"/"not found" reports calculated as true positives/(true positives+false negatives) were for the amphetamine specific assay 50%, methyl-amphetamines 93%, barbiturates 64%, cannabinoids 73%, cocaine and metabolites 100%, benzodiazepines 69%, methadone 95%, opiates 79% (opiates excluding oxycodone 93%), phencyclidine 93% and human gamma-globulin 97%. A small number of the sensitivity errors were attributable to errors in chromatographic confirmation techniques. |
Domaine : | Plusieurs produits / Several products |
Refs biblio. : | 8 |
Affiliation : | Altrix Healthcare plc, Birchwood Science Park, Warrington WA3 7BP. Royaume-Uni. United Kingdom. |
Cote : | R00164 |
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