Titre : | Methadone dose and neonatal abstinence syndrome-systematic review and meta-analysis (2010) |
Auteurs : | B. J. CLEARY ; J. DONNELLY ; J. STRAWBRIDGE ; P. J. GALLAGHER ; T. FAHEY ; M. CLARKE ; D. J. MURPHY |
Type de document : | Article : Périodique |
Dans : | Addiction (Vol.105, n°12, December 2010) |
Article en page(s) : | 2071-2084 |
Langues: | Anglais |
Discipline : | PAT (Pathologie organique / Organic pathology) |
Mots-clés : |
Thésaurus mots-clés GROSSESSE ; SUBSTITUTION ; NOUVEAU-NE ; SYNDROME DE SEVRAGE ; METHADONE ; TRAITEMENT DE MAINTENANCE |
Résumé : | AIM: To determine if there is a relationship between maternal methadone dose in pregnancy and the diagnosis or medical treatment of neonatal abstinence syndrome (NAS). METHODS: PubMed, EMBASE, the Cochrane Library and PsychINFO were searched for studies reporting on methadone use in pregnancy and NAS (1966-2009). The relative risk (RR) of NAS was compared for methadone doses above versus below a range of cut-off points. Summary RRs and 95% confidence intervals (CI) were estimated using random effects meta-analysis. Sensitivity analyses explored the impact of limiting meta-analyses to prospective studies or studies using an objective scoring system to diagnose NAS. RESULTS: A total of 67 studies met inclusion criteria for the systematic review; 29 were included in the meta-analysis. Any differences in the incidence of NAS in infants of women on higher compared with lower doses were statistically non-significant in analyses restricted to prospective studies or to those using an objective scoring system to diagnose NAS. CONCLUSIONS: Severity of the neonatal abstinence syndrome does not appear to differ according to whether mothers are on high- or low-dose methadone maintenance therapy. [Author's abstract] |
Domaine : | Drogues illicites / Illicit drugs |
Sous-type de document : | Méta-analyse / Meta-analysis ; Revue de la littérature / Literature review |
Refs biblio. : | 105 |
Affiliation : | Coombe Women and Infants University Hospital, Dublin 8, Ireland School of Pharmacy, Royal College of Surgeons in Ireland, Dublin 2, Ireland / Irlande |
Lien : | http://onlinelibrary.wiley.com/doi/10.1111/j.1360-0443.2010.03120.x/abstract |
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