| Titre : | Dopamine D2 receptor genotype is associated with increased mortality at a 10-year follow-up of alcohol-dependent individuals (2010) |
| Auteurs : | U. BERGGREN ; C. FAHLKE ; K. J. BERGLUND ; K. WADELL ; H. ZETTERBERG ; K. BLENNOW ; D. THELLE ; J. BALLDIN |
| Type de document : | Article : Périodique |
| Mention d'édition : | Alcohol and alcoholism (Oxford, Oxfordshire) |
| Dans : | Alcohol and Alcoholism (Vol.45, n°1, January-February 2010) |
| Article en page(s) : | pp. 1-5 |
| Langues: | Anglais |
| Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
| Mots-clés : |
Thésaurus mots-clés GENETIQUE ; FACTEUR DE RISQUE ; ETUDE LONGITUDINALE ; EPIDEMIOLOGIE DESCRIPTIVE ; ALCOOL ; MORTALITE |
| Résumé : | AIMS: Because the TAQ1 A1 allele may be associated with alcohol-related medical illnesses, and medical illnesses in alcohol-dependent individuals are associated with increased mortality, we test the hypothesis that the TAQ1 A1 allele of the DRD2 gene is associated with increased mortality in alcohol-dependent individuals. METHODS: Following an index treatment episode, a 10-year follow-up study in 366 alcohol-dependent individuals was performed. The TAQ1 A1/A2 DRD2 genotype and allele frequencies were compared between those deceased and those still living at the 10-year point. In addition, the genotype and allele frequencies of these alcohol-dependent individuals were compared to that in 578 control subjects. RESULTS: The prevalence of the A1 allele differed between the deceased and living patients and the controls: 47% of the deceased were A1+, compared to 37% of the living patients and 32% of the controls. The frequency of the TAQ1 A1/A2 genotype also differed between the groups. Thus, 43% had the A1/A2 genotype in comparison with 32% in the living patients and 29% in the controls. The TAQ 1 A1 allele frequency differed between the groups. The frequency of A1 allele was 25% in the deceased patients compared to 21% in the living patients and 17% in the controls. CONCLUSION: The TAQ I A1 allele of the DRD2 gene (or DRD2 gene region) was associated with increased mortality over a 10-year period in alcohol-dependent individuals. |
| Domaine : | Alcool / Alcohol |
| Refs biblio. : | 24 |
| Centre Emetteur : | 13 OFDT |
| Lien : | http://www.ncbi.nlm.nih.gov/pubmed/19654188 |
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