Titre : | The human toxicity of marijuana |
Titre traduit : | (Toxicité génrérale du cannabis) |
Auteurs : | G. NAHAS ; C. LATOUR |
Type de document : | Périodique |
Année de publication : | 1992 |
Format : | 495-497 |
Note générale : |
Medical Journal of Australia, 1992, 156, (7), 495-497 Voir aussi version française A00950 |
Langues: | Français |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus mots-clés CANNABIS ; TOXICITE ; EFFET SECONDAIRE ; FOETUS ; FUMER ; TETRAHYDROCANNABINOL ; EPIDEMIOLOGIE ; MODELE ANIMAL ; ENFANT D'USAGER ; CONDUITE DE VEHICULE ; SCHIZOPHRENIE ; PATHOLOGIE ORGANIQUE |
Résumé : |
ENGLISH : The pathophysiological effects of marijuana smoke and its constituent cannabinoids were reported first from in-vitro and in-vivo experimental studies. Marijuana smoke is mutagenic in the Ames test and in tissue culture and cannabinoids inhibit biosynthesis of macromolecules. In animals, marijuana or delta 9-tetrahydrocannabinol (THC), the intoxicating material it contains, produces symptoms of neurobehavioural toxicity, disrupts all phases of gonadal or reproductive function, and is fetotoxic. Smoking marijuana can lead to symptoms of airway obstruction as well as squamous metaplasia. Clinical manifestations of pathophysiology due to marijuana smoking are now being reported. These include: long-term impairment of memory in adolescents; prolonged impairment of psychomotor performance; a sixfold increase in the incidence of schizophrenia; cancer of mouth, jaw, tongue and lung in 19-30 year olds; fetotoxicity; and non-lymphoblastic leukemia in children of marijuana-smoking mothers. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 35 |
Affiliation : |
Laboratoire de Pharmacologie et Toxicologie Cellulaires, INSERM, Hôpital Fernand Widal, Paris France. France. |
Centre Emetteur : | 13 OFDT |
Cote : | A01004 |
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