Titre : | Cannabis use and psychosis: a longitudinal population-based study (2002) |
Titre traduit : | (Consommation de cannabis et psychose : étude longitudinale en population générale) |
Auteurs : | J. VAN OS ; M. BAK ; HANSSEN M. ; R. V. BIJL ; R. DE GRAAF ; H. VERDOUX |
Type de document : | Article : Périodique |
Dans : | American Journal of Epidemiology (Vol.156, n°4, August 2002) |
Article en page(s) : | 319-327 |
Langues: | Anglais |
Mots-clés : |
Thésaurus mots-clés CANNABIS ; TROUBLE BIPOLAIRE ; PSYCHOSE ; ETUDE LONGITUDINALE ; POPULATION GENERALE ; ENQUETEThésaurus géographique PAYS-BAS |
Résumé : |
ENGLISH :
Cannabis use may increase the risk of psychotic disorders and result in a poor prognosis for those with an established vulnerability to psychosis. A 3-year follow-up (1997-1999) is reported of a general population of 4,045 psychosis-free persons and of 59 subjects in the Netherlands with a baseline diagnosis of psychotic disorder. Substance use was assessed at baseline, 1-year follow-up, and 3-year follow-up. Baseline cannabis use predicted the presence at follow-up of any level of psychotic symptoms (adjusted odds ratio (OR) =2.76, 95% confidence interval (CI): 1.18, 6.47), as well as a severe level of psychotic symptoms (OR = 24.17, 95% CI: 5.44, 107.46), and clinician assessment of the need for care for psychotic symptoms (OR = 12.01, 95% CI: 2.24, 64.34). The effect of baseline cannabis use was stronger than the effect at 1-year and 3-year follow-up, and more than 50% of the psychosis diagnoses could be attributed to cannabis use. On the additive scale, the effect of cannabis use was much stronger in those with a baseline diagnosis of psychotic disorder (risk difference, 54.7%) than in those without (risk difference, 2.2%; p for interaction = 0.001). Results confirm previous suggestions that cannabis use increases the risk of both the incidence of psychosis in psychosis-free persons and a poor prognosis far those with an established vulnerability to psychotic disorder. |
Note de contenu : | tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 41 |
Affiliation : | Etats-Unis. United States. |
Numéro Toxibase : | 1300337 |
Centre Emetteur : | 13 OFDT |
Lien : | https://doi.org/10.1093/aje/kwf043 |
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