|Titre :||Association of road-traffic accidents with benzodiazepine use|
|Auteurs :||F. BARBONE ; F. BARBONE ; D. McMAHON ; P. DAVEY|
|Type de document :||Périodique|
|Année de publication :||1998|
|Format :||p.1331-1336 / tabl.|
|Note générale :||
Lancet (The), 1998, Vol.352, n°9137, p.1331-1336
|Discipline :||SHS (Sciences humaines et sociales / Human and social sciences)|
Thésaurus TOXIBASEACCIDENT ; CONDUITE DE VEHICULE ; BENZODIAZEPINES ; FACTEUR DE RISQUE ; ENQUETE ; ETUDE TRANSVERSALE
BACKGROUND. Psychomotor studies suggest that commonly prescribed psychoactive drugs impair driving skills. We have examined the association between the use of psychoactive drugs and road-traffic accidents.
METHODS. We used dispensed prescribing as a measure of exposure in a within-person case-crossover study of drivers aged 18 years and over, resident in Tayside, UK, who experienced a first road-traffic accident between Aug 1, 1992, and June 30, 1995, and had used a psychoactive drug (tricyclic antidepressant, benzodiazepine, selective serotonin-reuptake inhibitor, or other psychoactive drug [mainly major tranquillisers]) between Aug 1, 1992, and the date of the accident. For each driver, the risks of having a road-traffic accident while exposed and not exposed to a drug were compared.
FINDINGS. 19?386 drivers were involved in a first road-traffic accident during the study period. 1731 were users of any study drug. On the day of the accident, 189 individuals were taking tricyclic antidepressants (within-patient exposure odds ratio for an accident 0·93 [95% CI 0·72–1·21]), 84 selective serotonin-reuptake inhibitors (0·85 [0·55–1·33]), 235 benzodiazepines (1·62 [1·24–2·12]), and 47 other psychoactive drugs (0·88 [0·62–1·25]). The risk associated with benzodiazepine use decreased with increasing driver's age and was greater when the breath test for alcohol was positive. A dose-response relation was evident with benzodiazepines. The increased risk with benzodiazepines was significant for long-half-life drugs, used as anxiolytics, and for short-half-life hypnotics (all zopiclone).
INTERPRETATION. Users of anxiolytic benzodiazepines and zopiclone were at increased risk of experiencing a road-traffic accident. Users of anxiolytic benzodiazepines and zopiclone should be advised not to drive.
|Domaine :||Autres substances / Other substances|
|Refs biblio. :||31|
|Affiliation :||Medicines Monitoring Unit, Department of Clinical Pharmacology and Therapeutics, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY Royaume-Uni. United Kingdom.|
|Centre Emetteur :||13 OFDT|