Titre : | Association of road-traffic accidents with benzodiazepine use |
Auteurs : | F. BARBONE ; F. BARBONE ; D. McMAHON ; P. DAVEY |
Type de document : | Périodique |
Année de publication : | 1998 |
Format : | p.1331-1336 / tabl. |
Note générale : |
Lancet (The), 1998, Vol.352, n°9137, p.1331-1336
|
Langues: | Anglais |
Discipline : | SHS (Sciences humaines et sociales / Humanities and social sciences) |
Mots-clés : |
Thésaurus mots-clés ACCIDENT ; CONDUITE DE VEHICULE ; BENZODIAZEPINES ; FACTEUR DE RISQUE ; ENQUETE ; ETUDE TRANSVERSALEThésaurus géographique ETATS-UNIS |
Résumé : |
BACKGROUND. Psychomotor studies suggest that commonly prescribed psychoactive drugs impair driving skills. We have examined the association between the use of psychoactive drugs and road-traffic accidents.
METHODS. We used dispensed prescribing as a measure of exposure in a within-person case-crossover study of drivers aged 18 years and over, resident in Tayside, UK, who experienced a first road-traffic accident between Aug 1, 1992, and June 30, 1995, and had used a psychoactive drug (tricyclic antidepressant, benzodiazepine, selective serotonin-reuptake inhibitor, or other psychoactive drug [mainly major tranquillisers]) between Aug 1, 1992, and the date of the accident. For each driver, the risks of having a road-traffic accident while exposed and not exposed to a drug were compared. FINDINGS. 19?386 drivers were involved in a first road-traffic accident during the study period. 1731 were users of any study drug. On the day of the accident, 189 individuals were taking tricyclic antidepressants (within-patient exposure odds ratio for an accident 0·93 [95% CI 0·72–1·21]), 84 selective serotonin-reuptake inhibitors (0·85 [0·55–1·33]), 235 benzodiazepines (1·62 [1·24–2·12]), and 47 other psychoactive drugs (0·88 [0·62–1·25]). The risk associated with benzodiazepine use decreased with increasing driver's age and was greater when the breath test for alcohol was positive. A dose-response relation was evident with benzodiazepines. The increased risk with benzodiazepines was significant for long-half-life drugs, used as anxiolytics, and for short-half-life hypnotics (all zopiclone). INTERPRETATION. Users of anxiolytic benzodiazepines and zopiclone were at increased risk of experiencing a road-traffic accident. Users of anxiolytic benzodiazepines and zopiclone should be advised not to drive. |
Domaine : | Autres substances / Other substances |
Refs biblio. : | 31 |
Affiliation : |
Medicines Monitoring Unit, Department of Clinical Pharmacology and Therapeutics, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY Royaume-Uni. United Kingdom. |
Centre Emetteur : | 13 OFDT |
Cote : | A01312 |
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