Titre : | Transition from moderate to excessive drug intake: change in hedonic set point |
Titre traduit : | (Passage d'une prise de drogue modérée vers une consommation excessive) |
Auteurs : | S. H. AHMED ; G. F. KOOB |
Type de document : | Périodique |
Année de publication : | 1998 |
Format : | 298-300 / graph. |
Note générale : |
Science, 1998, 282, (5387), 298-300 |
Langues: | Français |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus mots-clés MODELE ANIMAL ; AUTOADMINISTRATION ; COCAINE ; DOSE-REPONSE ; USAGE REGULIER ; ABUS ; THEORIE DE L'ESCALADE |
Résumé : |
ENGLISH : Differential access to cocaine self-administration produced two patterns of drug intake in rats. With 1 hour of access per session, drug intake remained low and stable. In contrast, with 6 hours of access, drug intake gradually escalated over days. After escalation, drug consumption was characterized by an increased early drug loading and an upward shift in the cocaine dose-response function, suggesting an increase in hedonic set point. After 1 month of abstinence, escalation of cocaine intake was reinstated to a higher level than before. These findings may provide an animal model for studying the development of excessive drug intake and the basis of addiction. (Review' s abstract) |
Note de contenu : | graph. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 15 |
Affiliation : |
Division of Psychopharmacology, Dpt of Neuropharmacology, CVN-7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 Etats-Unis. United States. |
Numéro Toxibase : | 1300988 |
Centre Emetteur : | 13 OFDT |
Cote : | A01791 |
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