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Methadone maintenance reduces heroin- and cocaine-induced relapse without affecting stress-induced relapse in a rodent model of poly-drug use
(Le traitement de maintenance à la méthadone reduit les rechutes induites par l'héroïne et la cocaïne sans influer sur les rechutes dûes au stress chez le rat utilisé comme modèle animal de polyconsommation)
Auteur(s) :
LERI, F. ;
TREMBLAY, A. ;
SORGE, R. E. ;
STEWART, J.
Année :
2004
Page(s) :
1312-1320
Langue(s) :
Français
Refs biblio. :
93
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
MODELE ANIMAL
;
ANIMAL
;
TRAITEMENT DE MAINTENANCE
;
METHADONE
;
RECHUTE
;
COCAINE
;
HEROINE
;
STRESS
;
AUTOADMINISTRATION
Note générale :
Neuropsychopharmacology, 2004, 29, (7), 1312-1320
Note de contenu :
graph.
Résumé :
ENGLISH :
Although it is well established that methadone can be an effective treatment for opiate addiction, it is not clear how methadone maintenance affects cocaine use and cravings in individuals who self-administer both opiates and cocaine. In our attempt to explore the effect of methadone maintenance on the effects of cocaine, we first assessed the locomotor stimulatory effects of cocaine in rats maintained on methadone (0, 10, 20, or 30 mg/kg/day, via osmotic minipumps). Chronic methadone elevated baseline locomotion in a dose-dependent manner and did not reduce the direct stimulatory effects of cocaine (5 mg/kg). We then investigated the effects of the highest methadone maintenance dose (30 mg/kg/day) on heroin and cocaine seeking in extinction, and when it was precipitated by exposure to heroin, cocaine, or foot-shock stress in rats trained to self-administer both drugs in the same experimental context (heroin 0.05 mg/kg/inf; cocaine 0.5 mg/kg/inf, eight 3-h sessions each). In tests of reinstatement, rats responded selectively on the appropriate drug-associated lever after priming injections of heroin (0.25 mg/kg) or cocaine (20 mg/kg). Methadone maintenance blocked both cocaine- and heroin-induced reinstatement, but not stress-induced reinstatement, which was not lever selective. These results suggest that although methadone maintenance may not reduce the direct stimulatory effects of cocaine, it has the potential to reduce both spontaneous and cocaine-primed cocaine-seeking behavior.
Affiliation :
Dpt of Psychology, Univ. of Guelph, Guelph, Ontario
Canada. Canada.
Canada. Canada.
Cote :
A01832