Titre : | Pharmacology of cannabinoids |
Titre traduit : | (La pharmacologie des cannabinoïdes) |
Auteurs : | F. GROTENHERMEN |
Type de document : | Périodique |
Année de publication : | 2004 |
Format : | 14-23 / tabl. |
Note générale : |
Neuroendocrinology Letters, 2004, 25, (1/2), 14-23 |
Langues: | Français |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus mots-clés CANNABINOIDES ; MECANISME D'ACTION ; CANNABIS ; TETRAHYDROCANNABINOL ; PHARMACOLOGIE ; RECEPTEUR ; USAGE THERAPEUTIQUE ; INTERACTION CHIMIQUE |
Résumé : |
ENGLISH : Dronabinol (delta9-tetrahydocannabinol, THC), the main source of the pharmacological effects caused by the use of cannabis, is an agonist to both the CB1 and the CB2 subtype of cannabinoid receptors. It is available on prescription in several countries. The non-psychotropic cannabidiol (CBD), some analogues of natural cannabinoids and their metabolites, antagonists at the cannabinoid receptors and modulators of the endogenous cannabinoid system are also promising candidates for clinical research and therapeutic uses. Cannabinoid receptors are distributed in the central nervous system and many peripheral tissues including spleen, leukocytes; reproductive, urinary and gastrointestinal tracts; endocrine glands, arteries and heart. Five endogenous cannabinoids have been detected so far, of whom anandamide and 2-arachidonylglycerol are best characterized. There is evidence that besides the two cannabinoid receptor subtypes cloned so far additional cannabinoid receptor subtypes and vanilloid receptors are involved in the complex physiological functions of the cannabinoid system that include motor coordination, memory procession, control of appetite, pain modulation and neuroprotection. Strategies to modulate their activity include inhibition of re-uptake into cells and inhibition of their degradation to increase concentration and duration of action. Properties of cannabinoids that might be of therapeutic use include analgesia, muscle relaxation, immunosuppression, anti-inflammation, anti-allergic effects, sedation, improvement of mood, stimulation of appetite, anti-emesis, lowering of intraocular pressure, bronchodilation, neuroprotection and antineoplastic effects. (Author' s abstract) |
Note de contenu : | tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Sous-type de document : | Revue de la littérature / Literature review |
Refs biblio. : | 148 |
Affiliation : |
Nova-Institut, D-50354 Hürth Allemagne. Germany. |
Numéro Toxibase : | 1301190 |
Centre Emetteur : | 13 OFDT |
Cote : | A02181 |
Lien : | http://www.nel.edu/ |
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