Titre : | Effectiveness of highly active antiretroviral therapy among injection drug users with late-stage human immunodeficiency virus infection (2005) |
Titre traduit : | (Efficacité d'une thérapie antirétrovirale hautement active chez les usagers de drogue par voie intraveineuse, infectés par le VIH à un stade avancé.) |
Auteurs : | D. VLAHOV ; N. GALAI ; SAFAEIAN M. ; S. GALEA ; G. KIRK ; T. STERLING |
Type de document : | Article : Périodique |
Dans : | American Journal of Epidemiology (Vol.161, n°11, June 1, 2005) |
Article en page(s) : | 999-1012 |
Langues: | Anglais |
Discipline : | MAL (Maladies infectieuses / Infectious diseases) |
Mots-clés : |
Thésaurus mots-clés INJECTION ; ANTIRETROVIRAUX ; SIDA ; TRAITEMENT ; VIH ; ENQUETE ; EPIDEMIOLOGIE ; MORTALITE ; USAGER |
Résumé : | Highly active antiretroviral therapy (HAART) has been shown to be effective in different populations, but data among injection drug users are limited. Human immunodeficiency virus-infected injection drug users recruited into the Acquired Immunodeficiency Syndrome Link to Intravenous Experiences (ALIVE) Study as early as 1988 were tested semiannually to identify their first CD4-positive T-lymphocyte cell count below 200/µl; they were followed for mortality through 2002. Visits were categorized into the pre-HAART (before mid-1996) and the HAART eras and further categorized by HAART use. Survival analysis with staggered entry was used to evaluate the effect of HAART on acquired immunodeficiency syndrome-related mortality, adjusting for other medications and demographic, clinical, and behavioral factors. Among 665 participants, 258 died during 2,402 person-years of follow-up. Compared with survival in the pre-HAART era, survival in the HAART era was shown by multivariate analysis to be improved for both those who did and did not receive HAART (relative hazards = 0.06 and 0.33, respectively; p |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 40 |
Affiliation : | USA |
Numéro Toxibase : | 1301167 |
Centre Emetteur : | 13 OFDT |
Lien : | https://doi.org/10.1093/aje/kwi133 |
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