Historique
Article de Périodique
Effectiveness of highly active antiretroviral therapy among injection drug users with late-stage human immunodeficiency virus infection (2005)
(Efficacité d'une thérapie antirétrovirale hautement active chez les usagers de drogue par voie intraveineuse, infectés par le VIH à un stade avancé.)
Auteur(s) :
D. VLAHOV ;
N. GALAI ;
SAFAEIAN M. ;
S. GALEA ;
G. KIRK ;
T. STERLING
Article en page(s) :
999-1012
Refs biblio. :
40
Domaine :
Drogues illicites / Illicit drugs
Langue(s) :
Anglais
Discipline :
MAL (Maladies infectieuses / Infectious diseases)
Thésaurus mots-clés
INJECTION
;
ANTIRETROVIRAUX
;
SIDA
;
TRAITEMENT
;
VIH
;
ENQUETE
;
EPIDEMIOLOGIE
;
MORTALITE
;
USAGER
Résumé :
Highly active antiretroviral therapy (HAART) has been shown to be effective in different populations, but data among injection drug users are limited. Human immunodeficiency virus-infected injection drug users recruited into the Acquired Immunodeficiency Syndrome Link to Intravenous Experiences (ALIVE) Study as early as 1988 were tested semiannually to identify their first CD4-positive T-lymphocyte cell count below 200/µl; they were followed for mortality through 2002. Visits were categorized into the pre-HAART (before mid-1996) and the HAART eras and further categorized by HAART use. Survival analysis with staggered entry was used to evaluate the effect of HAART on acquired immunodeficiency syndrome-related mortality, adjusting for other medications and demographic, clinical, and behavioral factors. Among 665 participants, 258 died during 2,402 person-years of follow-up. Compared with survival in the pre-HAART era, survival in the HAART era was shown by multivariate analysis to be improved for both those who did and did not receive HAART (relative hazards = 0.06 and 0.33, respectively; p
Affiliation :
USA