Périodique
The differential impact of risk factors on illicit drug involvement in females
(L'impact différentiel des facteurs de risque d'immersion dans la drogue chez les femmes)
Auteur(s) :
AGRAWAL, A. ;
GARDNER, C. O. ;
PRESCOTT, C. A. ;
KENDLER, K. S.
Année :
2005
Page(s) :
454-466
Langue(s) :
Anglais
Refs biblio. :
96
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PSY (Psychopathologie / Psychopathology)
Thésaurus mots-clés
TYPE D'USAGE
;
SEXE FEMININ
;
FACTEUR DE RISQUE
;
PRODUIT ILLICITE
;
FRATRIE
;
ADULTE
;
MILIEU SOCIOCULTUREL
;
RELIGION
;
STRUCTURE DE LA PERSONNALITE
;
ABUS SEXUEL
;
PSYCHOPATHOLOGIE
Thésaurus géographique
ETATS-UNIS
Note générale :
Social Psychiatry and Psychiatric Epidemiology, 2005, 40, (6), 454-466
Résumé :
Background: Initiation of drug use and progression to abuse/dependence involve complex pathways. Potential risk factors may correlate with initiation or progression or both. Are there risk factors that associate with illicit drug use or illicit drug abuse/dependence? Is the magnitude of the association the same for use and abuse/dependence? Does this pattern of association differ across categories of drugs? Methods: We used data from female-female adult twins to assess the association of 26 putative risk factors with use and abuse/dependence of six illicit psychoactive drugs. Drug involvement was represented by independent dichotomous outcomes and by a single ordinal variable. Odds ratios were obtained by logistic regression and a continuation ratio was used to test the magnitude of association. Results: Factors associate in similar patterns with different drug categories. Some associated factors interact only with initiation while others relate with both stages. There is a stronger association of significant socio-demographic factors with drug use while the psychiatric diagnoses are more strongly associated with progression to abuse/dependence. Conclusions: Risk factors may be use-specific, abuse/dependence-specific or common to use and abuse/dependence. The trend of associations is similar across different illicit drugs. This suggests complex, interacting pathways that determine drug habits in individuals. These results are hypothesis-generating and future studies of causal relationships may draw from the outcomes presented in these analyses. (Author' s abstract)
Affiliation :
Washington Univ., School of Medicine, Dept. of Psychiatry, 40 N. Kingshighway, Ste 2, St. Louis (MO) 63108.
Etats-Unis. United States.
Etats-Unis. United States.
Cote :
A02268