| Titre : | Addiction: a disease of learning and memory (2005) |
| Auteurs : | S. E. HYMAN |
| Type de document : | Article : Périodique |
| Dans : | American Journal of Psychiatry (Vol.162, n°8, August 2005) |
| Article en page(s) : | 1414-1422 |
| Langues: | Anglais |
| Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
| Mots-clés : |
Thésaurus mots-clés DEPENDANCE ; MEMOIRE ; NEUROBIOLOGIE ; APPRENTISSAGE ; TROUBLES DE LA MEMOIRE ; DOPAMINE ; CERVEAU |
| Résumé : | If neurobiology is ultimately to contribute to the development of successful treatments for drug addiction, researchers must discover the molecular mechanisms by which drug-seeking behaviors are consolidated into compulsive use, the mechanisms that underlie the long persistence of relapse risk, and the mechanisms by which drug-associated cues come to control behavior. Evidence at the molecular, cellular, systems, behavioral, and computational levels of analysis is converging to suggest the view that addiction represents a pathological usurpation of the neural mechanisms of learning and memory that under normal circumstances serve to shape survival behaviors related to the pursuit of rewards and the cues that predict them. The author summarizes the converging evidence in this area and highlights key questions that remain. (Author' s abstract) |
| Domaine : | Plusieurs produits / Several products |
| Sous-type de document : | Revue de la littérature / Literature review |
| Refs biblio. : | 99 |
| Affiliation : | Department of Neurobiology, Harvard Medical School, Boston, MA, USA |
| Centre Emetteur : | 13 OFDT |
| Cote : | A02345 |
| Lien : | http://dx.doi.org/10.1176/appi.ajp.162.8.1414 |
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