Titre : | Mechanisms of neurotransmitter release by amphetamines: a review |
Titre traduit : | (Les mécanismes de la libération de neurotransmetteur par les amphétamines : une revue de la littérature) |
Auteurs : | SULZER D. ; M. S. SONDERS ; POULSEN N. W. ; GALLI A. |
Type de document : | Périodique |
Année de publication : | 2005 |
Format : | 406-433 |
Note générale : |
Progress in Neurobiology, 2005, 75, (6), 406-433 |
Langues: | Français |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus mots-clés STIMULANTS ; MECANISME D'ACTION ; AMPHETAMINES ; NEUROBIOLOGIE ; NEUROTRANSMETTEURS ; CATECHOLAMINES |
Résumé : |
ENGLISH : Amphetamine and substituted amphetamines, including methamphetamine, methylphenidate (Ritalin), methylenedioxymethamphetamine (ecstasy), and the herbs khat and ephedra, encompass the only widely administered class of drugs that predominantly release neurotransmitter, in this case principally catecholamines, by a non-exocytic mechanism. These drugs play important medicinal and social roles in many cultures, exert profound effects on mental function and behavior, and can produce neurodegeneration and addiction. Numerous questions remain regarding the unusual molecular mechanisms by which these compounds induce catecholamine release. We review current issues on the two apparent primary mechanisms--the redistribution of catecholamines from synaptic vesicles to the cytosol, and induction of reverse transport of transmitter through plasma membrane uptake carriers--and on additional drug effects that affect extracellular catecholamine levels, including uptake inhibition, effects on exocytosis, neurotransmitter synthesis, and metabolism. (Author' s abstract) |
Domaine : | Autres substances / Other substances |
Sous-type de document : | Revue de la littérature / Literature review |
Refs biblio. : | 251 |
Affiliation : |
Dpt. of Psychiatry, Neurology and Pharmacology, New York State Psychiatric Inst., Columbia Univ., 650 W. 168th Street, Black Building Room 309, New York, NY 10032. Email : ds43@columbia.edu Etats-Unis. United States. |
Numéro Toxibase : | 1301320 |
Centre Emetteur : | 13 OFDT |
Cote : | A02348 |
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