Titre : | Description of a new hepatitis C risk assessment tool |
Auteurs : | M. T. NGUYEN ; S. K. HERRINE ; LAINE C. A. ; RUTH K. ; WEINBERG D. S. |
Type de document : | Périodique |
Année de publication : | 2005 |
Format : | 2013-2018 |
Note générale : |
Archives of Internal Medicine, 2005, 165, (17), 2013-2018 |
Langues: | Anglais |
Discipline : | MAL (Maladies infectieuses / Infectious diseases) |
Mots-clés : |
Thésaurus mots-clés HEPATITE ; FACTEUR DE RISQUE ; ETUDE TRANSVERSALE ; INFECTION ; EVALUATION ; DEPISTAGE ; MODELEThésaurus géographique ETATS-UNIS |
Résumé : |
ENGLISH : BACKGROUND: Because of the low prevalence of hepatitis C virus (HCV) infection in the general population, mass screening would be expensive and of low yield. Some researchers advocate targeted screening of persons at elevated HCV risk. METHODS: This cross-sectional study aimed to develop a patient-administered tool to assess HCV infection risk. Two hundred seven patients with unknown HCV status from a general medicine practice and 222 HCV-positive patients from a hepatology practice completed a 72-item survey about demographic, social, and clinical risk factors for HCV infection. General medicine patients also underwent HCV serologic testing. RESULTS: Three (1.5%) of 207 general medicine patients had positive HCV antibody test results. These patients plus the 222 hepatology patients were significantly more likely than HCV-negative patients to report an array of factors. In a multivariable model, 7 factors remained significantly associated with HCV infection: sex with a prostitute or an injecting drug user, exposure to blood products, refusal as a blood donor or as a life insurance applicant, witnessing illicit drug use, and self-reported HBV infection. A simplified model that assigned 1 point for each factor present predicted HCV infection as well as a weighted model (based on chi(2) testing and receiver operating characteristic curve comparison). In a population with a 2% prevalence of HCV infection, people who identified 2 risk factors had a 10% chance of HCV infection, whereas those with 4 or more risk factors had a 50% chance. CONCLUSIONS: A self-administered 72-item questionnaire can stratify patients into HCV risk groups. If validated in other primary care populations, this instrument could help target HCV screening. (Author' s abstract) |
Domaine : | Hors addiction / No addiction |
Affiliation : |
Fox Chase Cancer Center, Philadelphia, PA 19111. Email : david.weinberg@fccc.edu Etats-Unis. United States. |
Centre Emetteur : | 13 OFDT |
Cote : | A02423 |
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