Titre : | Deaths involving buprenorphine: a compendium of French cases |
Titre traduit : | (Les décès impliquant la buprénorphine : un condensé de cas français) |
Auteurs : | P. KINTZ |
Type de document : | Périodique |
Année de publication : | 2001 |
Format : | 65-69 |
Note générale : |
Forensic Science International, 2001, 121, (1-2), 65-69 |
Langues: | Français |
Mots-clés : |
Thésaurus mots-clés MORTALITE ; BUPRENORPHINE ; MESURES QUANTITATIVES ; SANG ; TOXICOLOGIE ; INTERACTION CHIMIQUE ; MEDICAMENTS ; METABOLITEThésaurus géographique FRANCE |
Résumé : |
ENGLISH : Buprenorphine at high dosage became available in France in 1996, as a substitution treatment for heroin addicts. Since this date, numerous deaths were attributed to this drug. This paper reports two original series of 39 and 78 fatalities involving buprenorphine observed at the Institute of Legal Medicine of Strasbourg and at 13 other French forensic centers, respectively. The files were recorded from January 1996May 2000. The first 20 fatalities that were previously published were excluded from this epidemiological study. From these 117 subjects, 96 were male (82%). Buprenorphine and its primary metabolite norbuprenophine were assayed in post-mortem blood by HPLC/MS (n=11 labs) or by GC/MS (n=3 labs). Blood levels for buprenorphine ranged from 0.5 to 51.0 ng/ml (mean 10.2 ng/ml) and 0.1 to 76 ng/ml (mean 12.6 ng/ml) in Strasbourg and the other centers, respectively. Blood levels for norbuprenorphine ranged from 0.2 to 47.1 ng/ml (mean 8.2 ng/ml) and |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 14 |
Affiliation : |
Institut de Médecine Légale, Univ. Louis Pasteur (ULP), 11 rue Humann, 67000 Strasbourg France. France. |
Numéro Toxibase : | 1301689 |
Centre Emetteur : | 13 OFDT |
Cote : | A02769 |
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